The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …

Background DNA methylation (DNAm) age acceleration (AgeAccel) has been shown to be
predictive of all-cause mortality but it is unclear what functional aspect (s) of aging it …

Robust biomarkers of aging have been developed from DNA methylation in humans and
more recently, in mice. This study aimed to generate a novel epigenetic clock in rats—a …

The molecular mechanisms of aging are the subject of much research and have facilitated
potential interventions to delay aging and aging-related degenerative diseases in humans …

Background Advanced age is associated with cognitive and physical decline and is a major
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of
aging and the role of epigenetic factors in mediating the link between early-life experiences …

Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …

Background Recently, epigenetic age acceleration—or older epigenetic age in comparison
to chronological age—has been robustly associated with mortality and various morbidities …

It is now well established that the genomic landscape of DNA methylation (DNAm) gets
altered as a function of age, a process we here call 'epigenetic drift'. The biological …

Introduction The “epigenetic clock” is a DNA methylation–based estimate of biological age
and is correlated with chronological age—the greatest risk factor for Alzheimer's disease …