Interactions of SARS-CoV-2 with the blood–brain barrier

MA Erickson, EM Rhea, RC Knopp… - International Journal of …, 2021 - mdpi.com
… and brain compartments and … SARS-CoV-2 interactions with the brain. In this review, we
evaluate the participation of the BBB in SARS-CoV-2 infections that could contribute to COVID-19

Neurological complications associated with the blood-brain barrier damage induced by the inflammatory response during SARS-CoV-2 infection

I Alquisiras-Burgos, I Peralta-Arrieta… - Molecular …, 2021 - Springer
… Consequently, the virus’ ability to infect brain cells and induce the inflammatory response …
patients with SARS-CoV-2 infection and its association with the blood-brain barrier integrity. …

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2

S Krasemann, U Haferkamp, S Pfefferle, MS Woo… - Stem cell reports, 2022 - cell.com
… While BCECs were not compromised in their paracellular tightness, we found SARS-CoV-2
of virus across the blood-brain barrier (BBB) in vitro. Moreover, entry of SARS-CoV-2 into …

SARS-COV2 alters blood brain barrier integrity contributing to neuro-inflammation

JL Reynolds, SD Mahajan - Journal of Neuroimmune Pharmacology, 2021 - Springer
… However, we believe, that SARS-COV-2 associated endothelial cell dysfunction preludes
the neuropathology associated with SARS-COV-2 that is observed in COVID-19 infected …

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration

L Zhang, L Zhou, L Bao, J Liu, H Zhu, Q Lv… - Signal transduction and …, 2021 - nature.com
… invading the brains of humans and model animals. However, it remains unclear whether
and how SARS-CoV-2 crosses the blood–brain barrier (BBB). Herein, SARS-CoV-2 RNA was …

Anti–SARS-CoV-2 antibodies in the CSF, blood-brain barrier dysfunction, and neurological outcome: studies in 8 stuporous and comatose patients

H Alexopoulos, E Magira, K Bitzogli… - Neurology …, 2020 - AAN Enterprises
… –SARS-CoV-2 IgG intrathecal synthesis, and 3 others had disruption of the blood-brain barrier.
… negative for autoimmune encephalitis antibodies and SARS-CoV-2 by PCR. None of the …

[HTML][HTML] The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

EM Rhea, AF Logsdon, KM Hansen, LM Williams… - Nature …, 2021 - nature.com
SARS-CoV-2 mRNA has been recovered from the cerebrospinal fluid 4 , suggesting it can …
blood–brain barrier (BBB). Other coronaviruses, including the closely related SARS virus that …

SARS-CoV-2 poorly replicates in cells of the human blood-brain barrier without associated deleterious effects

O Constant, J Barthelemy, K Bollore, E Tuaillon… - Frontiers in …, 2021 - frontiersin.org
… Finally, using serum samples from COVID-19 patients, we highlighted strong concentrations
of pro… of brain access following SARS-CoV-2 infection does not seem to be directed by brain

… disease 2019: neuroinflammation and blood brain barrier disruption are critical pathophysiological processes that contribute to the clinical symptoms of SARS-CoV-2 …

MO Welcome, NE Mastorakis - Inflammopharmacology, 2021 - Springer
2 (ACE2) with increased activity of the transmembrane protease serine 2 (TMPRSS2) and
cathepsin L in SARS-CoV-2 … response and blood brain barrier disruption. Furthermore, …

Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system

P Wang, L Jin, M Zhang, Y Wu, Z Duan, Y Guo… - Nature Biomedical …, 2023 - nature.com
… blood–brain barrier (BBB) tissue chips that recapitulates neuropathogenesis associated
with infection by SARS-CoV-2. Direct exposure of the BBB chip to SARS-CoV-2 caused mild …