Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

Y Zhou, J Xu, Y Hou, JB Leverenz, A Kallianpur… - Alzheimer's research & …, 2021 - Springer
SARS-CoV-2 affect the brain, including direct brain invasion, … COVID-19 patients, (2) the
expression of SARS-CoV-2 host factors in AD patients and healthy individuals at tissues, brain

… disease 2019: neuroinflammation and blood brain barrier disruption are critical pathophysiological processes that contribute to the clinical symptoms of SARS-CoV-2 …

MO Welcome, NE Mastorakis - Inflammopharmacology, 2021 - Springer
… The SARS-CoV-2 invasion of the brain may cause cerebral vascular/endothelial … of
SARS-CoV-2 infection as reported by Mao et al. (2020b), Al Saiegh et al. (2020), and Helms et al. …

Neurotropism of SARS-CoV-2 and neurological diseases of the central nervous system in COVID-19 patients

S Veleri - Experimental brain research, 2022 - Springer
… a neuro-invasion of the virus. This study also showed the presence of SARS-CoV-2 in the
cortical regions of post-mortem brains of the COVID-19 patients with encephalopathy. However…

[HTML][HTML] SARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability

F Crunfli, VC Carregari, FP Veras, PH Vendramini… - MedRxiv, 2021 - medrxiv.org
… astrocytes of COVID-19 patients Brain alterations in COVID-19 patients are hypothesized to
… to peripheral infection or SARS-CoV-2 invading the CNS and compromising cell viability and …

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels

E Cecon, D Fernandois, N Renault, CFF Coelho… - Cellular and Molecular …, 2022 - Springer
COVID-19 is a complex disease with short- and long-term respiratory, inflammatory and …
by the infection with SARS-CoV-2. Invasion of the brain by SARS-CoV-2 has been observed in …

Emerging neurotropic features of SARS-CoV-2

WR Zhan, J Huang, PM Zeng, WY Tian… - Journal of Molecular …, 2021 - academic.oup.com
… receptor, and other related proteins, it remains unclear whether the observed neurological
manifestations are attributed to virus invasion into the brain or just comorbidities caused by …

[HTML][HTML] Blood-brain barrier damage is pivotal for SARS-CoV-2 infection to the central nervous system

J Rodríguez-Morales… - Experimental …, 2022 - ncbi.nlm.nih.gov
… the SARS-CoV-2 infection to the CNS. Herein, we present the case reports of two patients
with a brain tumor and COVID-19… Consequently, it is feasible that SARS-CoV-2 can invade the …

[HTML][HTML] Pathophysiology of SARS-CoV-2 infection in patients with intracerebral hemorrhage

S Dong, P Liu, Y Luo, Y Cui, L Song, Y Chen - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
… after SARS-CoV-2 brain invasion in ICH patients. In a lab study, the serum samples of
SARS-CoV-2 … Because SARS-CoV-2 invades the brain via ACE2 receptor in ICH patients, viral …

SARS-CoV-2 attacks in the brain: Focus on the sialome

P Wielgat, K Narejko, H Car - Cells, 2022 - mdpi.com
SARS-CoV-2 invasion depends on scenarios that include various types of cells involved in
the mechanism of virus attachment and cell entry in the brain… target for SARS-CoV-2. However…

[HTML][HTML] The role of gut-brain axis in SARA-CoV-2 neuroinvasion: Culprit or innocent bystander?

Y Shi, Z Li, C Yang, C Liu - Brain, Behavior, and Immunity, 2021 - ncbi.nlm.nih.gov
… As we know, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly … virus
invasion. Collectively, these findings failed to support that SARS-CoV-2 could directly invade