[HTML][HTML] SARS-CoV-2 involvement in central nervous system tissue damage

MA Haidar, Z Shakkour, MA Reslan… - Neural Regeneration …, 2022 - journals.lww.com
… Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is
… by the virus. One possible theory is the invasion of SARS-CoV-2 to the brain occurs either …

[HTML][HTML] Long-term effects of SARS-CoV-2 in the brain: clinical consequences and molecular mechanisms

AC Granholm - Journal of Clinical Medicine, 2023 - mdpi.com
… In another postmortem study [113], the investigators reported neuro-invasion in the following
brain regions after SARS-CoV-2 infection: cranial nerve nuclei, olfactory bulb, motor nuclei …

[HTML][HTML] Neuroinvasion and encephalitis following intranasal inoculation of SARS-CoV-2 in K18-hACE2 mice

P Kumari, HA Rothan, JP Natekar, S Stone, H Pathak… - Viruses, 2021 - mdpi.com
… infection, and both viral proteins and infectious viral particle production were detected in
neurospheres and brain organoids infected with SARS-CoV-2 [18,19]. Human autopsy reports …

[HTML][HTML] Pathophysiological clues to how the emergent SARS-CoV-2 can potentially increase the susceptibility to neurodegeneration

M Dolatshahi, M Sabahi, MH Aarabi - Molecular neurobiology, 2021 - Springer
coronavirus 2 (SARS-CoV-2) in late 2019, a myriad of neurologic symptoms, associated with
structural brain … This virus can directly invade the brain through olfactory bulb, retrograde …

[HTML][HTML] The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

EM Rhea, AF Logsdon, KM Hansen, LM Williams… - Nature …, 2021 - nature.com
… of COVID-19 may be due to direct actions of the virus on the … to SARS-CoV-2 invading the
respiratory centers of the brain 1,… reported in COVID-19, and could be a result of virus or viral …

[HTML][HTML] Hypoxia modifies levels of the SARS-CoV-2 cell entry proteins, angiotensin-converting enzyme 2, and furin in fetal human brain endothelial cells

H Mughis, P Lye, SG Matthews, E Bloise - American Journal of Obstetrics & …, 2023 - Elsevier
… blood-brain barrier could potentially lead to altered SARS-CoV-2 brain invasion and
neurologic sequelae in neonates born to pregnancies complicated by SARS-CoV-2 infection. …

[HTML][HTML] Evidence of coronavirus (CoV) pathogenesis and emerging pathogen SARS-CoV-2 in the nervous system: a review on neurological impairments and …

NK Jha, S Ojha, SK Jha, H Dureja, SK Singh… - Journal of molecular …, 2021 - Springer
SARS virus particles as well as genome sequences in brain … CNS is invaded by SARS-CoV-2.
Few researchers have postulated plausible mechanisms of neuroinvasion of SARS-CoV-2

Ubiquity of the SARS-CoV-2 receptor ACE2 and upregulation in limbic regions of Alzheimer's disease brain

Y Zhao, W Li, W Lukiw - Folia neuropathologica, 2021 - termedia.pl
… pandemic (i) has created an unparalleled global health crisis; and (ii) our scientific understanding
of the mechanistic factors involved in SARS-CoV-2 transmission, invasion, viral spread …

SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders

N Amruta, WH Chastain, M Paz, RJ Solch… - Cytokine & growth factor …, 2021 - Elsevier
SARS-CoV-2 harbors an arginine-glycine-aspartate (RGD) motif and shows the involvement
of integrins in facilitating virus invasion … potential for the virus to enter brain endothelial cells …

[HTML][HTML] SARS-CoV-2:“Three-steps” infection model and CSF diagnostic implication

PP Panciani, G Saraceno, L Zanin… - Brain, behavior, and …, 2020 - ncbi.nlm.nih.gov
… This could be explained by the mechanism of CNS invasion by SARS-CoV-2 and the … The
SARS-CoV-2 reaches the brain via the bloodstream and/or trans-cribriform route along the …