… role of SARS-CoV-2 in modulating the function of brain pericytes via S … of brain pericytes in
response to SARS-CoV-2 S protein. Herein, we provide evidence indicating that SARS-CoV-2 …

… of disrupted pericyte homeostasis. We conclude that pericyte infection by SARS-CoV-2
underlies virus … due to perivascular inflammation and a locally compromised blood–brain barrier. …

… SARS-CoV-2 RBD on cerebral capillary pericyte function, we employed live imaging 26
of brain … Hamsters have an ACE2 sequence, in the part of the protein that binds the SARS-CoV-2 …

… This analysis confirmed that Ace2 is specifically expressed in brain pericytes, venous
VSMCs and Cnn1-negative arteriolar VSMCs (Fig 1a-c). An additional Ace2-positive cell cluster …

… susceptibility of brain pericytes to SARS-CoV-2 infection we specifically used brain pericyte-…
of human forebrain pericytes [45, 46]. BPLCs stained 100% positive for neural/glial antigen …

… identified pericytes in the vascular unit potentially mediate the entry of SARS-CoV-2 into the
brain and the spread to astrocytes (8), whose endfeet are in contact with pericytes. In PNAS, …

… Pericytes in the CNS, heart, and pancreas express ACE2 … In a number of other organs,
pericytes do not express ACE2, … , in brain pericytes before, and in heart pericytes after postnatal …

… Next, we found that reactive ACE2-expressing pericytes are … The result suggests that
ACE2-expressing pericytes reactivity … SARS-CoV-2 S protein is sufficient per se to induce pericyte …

… SARS-CoV-2 infection can cause BBB dysfunction, providing novel insights into the
understanding of SARS-CoV-2 … prevention and treatment of SARS-CoV-2-induced CNS infection. …

… cell types in brain tissue and elucidate potential routes of SARS-CoV-2 entry, we … of
SARS-CoV-2 lung tissue. [32,33] Therefore, pericytes may be the main target of SARS-CoV-2 in …