[PDF][PDF] Revealing tissue-specific SARS-CoV-2 infection and host responses using human stem cell-derived lung and cerebral organoids

SK Tiwari, S Wang, D Smith, AF Carlin, TM Rana - Stem Cell Reports, 2021 - cell.com
… Interestingly, our results also indicate that SARSCoV-2 infection activates the … (Figure 2G).
Together, our results demonstrate that SARS-CoV-2 robustly replicates in human LORGs and …

[HTML][HTML] Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment

R Rudraraju, MJ Gartner, JA Neil, ES Stout, J Chen… - Stem Cell Reports, 2023 - cell.com
… occur in severe coronavirus disease 2019 (COVID-19). To elucidate … in human stem
cell-derived lung alveolar type II (AT2) epithelial cell and cardiac cultures infected with SARS-CoV-2. …

[PDF][PDF] Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2-mediated interferon responses and pneumocyte dysfunction

H Katsura, V Sontake, A Tata, Y Kobayashi… - Cell stem cell, 2020 - cell.com
SARS-CoV-2 infection of 3D alveolosphere cultures of primary human alveolar epithelial
type-2 cells (AT2s), the stem … the highest enrichment of SARS-CoV-2 receptor ACE2, and its …

[PDF][PDF] A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids

L Yang, Y Han, BE Nilsson-Payant, V Gupta, P Wang… - Cell stem cell, 2020 - cell.com
… Infection Before validating permissiveness of primary human islets to SARS-CoV-2 virus,
we used single-cell RNA-sequencing to examine global transcript profiles and to define cell …

Human hematopoietic stem, progenitor, and immune cells respond ex vivo to SARS-CoV-2 spike protein

J Ropa, S Cooper, ML Capitano, W Van't Hof… - Stem cell reviews and …, 2021 - Springer
… acute respiratory syndrome (SARS) caused by the SARS coronavirus (SARS-CoV) in 2002
… (MERS) caused by the MERS coronavirus (MERS-CoV) in 2012. COVID-19 represents the …

[PDF][PDF] SARS-CoV-2 infection of pluripotent stem cell-derived human lung alveolar type 2 cells elicits a rapid epithelial-intrinsic inflammatory response

J Huang, AJ Hume, KM Abo, RB Werder… - Cell Stem Cell, 2020 - cell.com
… To test whether ALI cultures of iAT2s are permissive to SARSCoV-2 infection, we employed
escalating viral doses representing a broad range of multiplicities of infection (MOIs). iAT2s …

SARS-CoV-2 research using human pluripotent stem cells and organoids

S Deguchi, Á Serrano-Aroca… - Stem Cells …, 2021 - academic.oup.com
… Although many clinical trials are underway worldwide, basic research on SARS-CoV-2
human pluripotent stem cell-derived cells and organoids available for research on SARS-CoV-2, …

[PDF][PDF] Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2

J Youk, T Kim, KV Evans, YI Jeong, Y Hur, SP Hong… - Cell Stem Cell, 2020 - cell.com
… To further determine the subcellular consequences of SARSCoV-2 infection at higher
resolution, we performed transmission electron microscopy (TEM) analysis. Compared with …

[HTML][HTML] SARS-CoV-2 infection and stem cells: Interaction and intervention

F Yu, R Jia, Y Tang, J Liu, B Wei - Stem cell research, 2020 - Elsevier
… novel severe acute respiratory coronavirus 2 (SARS-CoV-2) in … SARS-CoV in spike protein
suggests that SARS-CoV-2 employs spike–driven entry into angiotensin-converting enzyme 2

[PDF][PDF] SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function

S Marchiano, TY Hsiang, A Khanna, T Higashi… - Stem cell reports, 2021 - cell.com
SARS-CoV-2 in human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and smooth
muscle cells (hPSC-SMCs). We find that that SARS-CoV-2 … , SARS-CoV-2 is assembled in …