… and cellular landscape of the aging human lung in relation to SARS-CoV-2. We find that
the … the transcriptome and cellular landscape of the aging human lung in relation to SARS-CoV-…

… , we investigated the whole blood transcriptome data during aging using the Genotype-Tissue …
age-associated target genes and how they can predict SARS-CoV-2 interactions in aged …

… In our present study, unbiased whole-transcriptome sequencing of isolated lung ECs from
aged humanized transgenic ACE2 mice showed less induction of adhesive markers (eg, Icam1…

… human coronavirus (HCoVs; SARS-CoV-2 and SARS-CoV) … ) data to test whether lung aging
is associated with transcriptional … Here, we used the transcriptome of lung samples from the …

… -2 induces a major change to the host cell’s transcriptome/… in older transcriptomes [89].
Secondly, ageing modulates the expression of proteins necessary for the viral cycle of SARS-CoV-…

… Finally, age-stratified SARS-CoV-2-positive human data revealed impaired upregulation
of chemokines, interferon-stimulated genes, and tripartite motif genes that are critical for …

… Using computational predictions of SARS-CoV–human … the whole blood transcriptome
data during aging using the … age-associated target genes and how they can predict SARS…

… 9c), suggesting dysfunction of age-related genes with the onset of SARS-CoV-2 infection. …
was perturbed by both age and SARS-CoV-2 infection. Aging and SARS-CoV-2 infection …

… with SARS-CoV-2 and ageing blood transcriptome. Pathway enrichment analysis of overlapping
gene sets suggest that infection alters expression of genes already dysregulated in the …

… This specific attenuated innate immune response could explain how older individuals, who
are likely to present age-related immune cell decline, are at risk for SARS-CoV-2 mortality. …