[HTML][HTML] Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug …

D Butler, C Mozsary, C Meydan, J Foox… - Nature …, 2021 - nature.com
… Defining the SARS-CoV-2 host transcriptome We then leveraged the total RNA-seq profiles
to better understand the host transcriptome during SARS-CoV-2 infection. Cell proportion …

[HTML][HTML] Changes in the innate immune response to SARS-CoV-2 with advancing age in humans

S Agrawal, MT Tran, TSK Jennings, MMH Soliman… - Immunity & …, 2024 - Springer
… to SARS-CoV-2 as a function of age. Our results using human PBMCs from aged, middle-aged, …
and monocytes in response to SARS-CoV-2 is compromised with age. The impairment is …

[HTML][HTML] Single-cell transcriptomic atlas of primate cardiopulmonary aging

S Ma, S Sun, J Li, Y Fan, J Qu, L Sun, S Wang, Y Zhang… - Cell research, 2021 - nature.com
… In addition, we have recently reported that SARS-CoV-2 promotes age-associated immune
cell polarization along with the expression of pro-inflammatory and pro-senescence genes …

[HTML][HTML] Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate …

ABMMK Islam, MAAK Khan, R Ahmed… - Journal of translational …, 2021 - Springer
… In this context, we aimed to discover the host transcriptome response upon SARS-CoV-2 …
Moreover, we compared the transcriptome from different SARS-CoV-2 infection models, …

[HTML][HTML] Detection of SARS-CoV-2 genome and whole transcriptome sequencing in frontal cortex of COVID-19 patients

S Gagliardi, ET Poloni, C Pandini, M Garofalo… - Brain, Behavior, and …, 2021 - Elsevier
… of COVID-19 for the presence of SARS-CoV-2, comparing qRT-… Our data showed that
SARS-CoV-2 could be detected by … Thus, it is likely that SARS-CoV-2 does not actively infect and …

[HTML][HTML] Shotgun transcriptome and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

DJ Butler, C Mozsary, C Meydan, D Danko, J Foox… - BioRxiv, 2020 - ncbi.nlm.nih.gov
… We applied both technologies across 857 SARS-CoV-2 … Our results define new features of
SARS-CoV-2 evolution, nominate a … have immediate applications to SARS-CoV-2 diagnostics, …

[HTML][HTML] Transcriptomic analysis of HCN-2 cells suggests connection among oxidative stress, senescence, and neuron death after SARS-CoV-2 infection

A Valeri, L Chiricosta, V Calcaterra, M Biasin… - Cells, 2021 - mdpi.com
… the effect of SARS-CoV-2 in this type of cells. Transcriptome analyses revealed impairment
in TXN … They are also known to correlate with aging, particularly age-related inflammation, as …

[HTML][HTML] Exacerbated innate host response to SARS-CoV in aged non-human primates

SL Smits, A de Lang, JMA van den Brand… - PLoS …, 2010 - journals.plos.org
… /ARDS in aged individuals are ill-defined. Here, we show that SARS-CoV-infected aged
macaques … These observations are largely in line with transcriptome analyses in mice and SARS

SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome

M Zaffagni, JM Harris, IL Patop, NR Pamudurti… - Elife, 2022 - elifesciences.org
… Here, we undertook transcriptome analyses in cells that express each SARS- CoV- 2
protein individually. Expression of Nsp14 altered the expression of about 4000 genes, mostly …

[PDF][PDF] The architecture of SARS-CoV-2 transcriptome

D Kim, JY Lee, JS Yang, JW Kim, VN Kim, H Chang - Cell, 2020 - cell.com
… the SARS-CoV-2 transcriptome and epitranscriptome. DNA nanoball sequencing shows that
the transcriptome … Thus, the short tails of $30 nt observed in this study may represent aged