Single nucleus multiomic profiling reveals age-dynamic regulation of host genes associated with SARS-CoV-2 infection

A Wang, J Chiou, OB Poirion, J Buchanan, MJ Valdez… - Biorxiv, 2020 - biorxiv.org
… The average number of nuclei that passed this threshold per age group was … Age-linked
increase in host genes for SARS-CoV-2 entry In total, 46,500 single nucleus transcriptomes

Tissue Specific Age Dependence of the Cell Receptors Involved in the SARS-CoV-2 Infection

CV Forst, L Zeng, Q Wang, X Zhou, S Vatansever, Z Tu… - bioRxiv, 2021 - biorxiv.org
… of transcriptome data to … SARS-CoV-2 DEGs and signatures responding to ACE2
overexpression. Finally, we analyzed the age-dependency of molecular processes during …

SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

S Tsuji, S Minami, R Hashimoto, Y Konishi, T Suzuki… - Nature aging, 2022 - nature.com
… with age 18 . However, judging from the expression of the proteins encoded by SARS-CoV-2
and the detection of SARS-CoV-… ), we were unable to detect SARS-CoV-2 infection in these …

A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients

A Sadanandam, T Bopp, S Dixit, DJHF Knapp… - Cell death …, 2020 - nature.com
… Although age and compromised health history are considered critical prognostic factors, …
the coronavirus infection, we used a limited RNA transcriptome data from PBMC of SARS-CoV

Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

HK Lee, L Knabl, L Pipperger, A Volland, PA Furth… - Scientific reports, 2021 - nature.com
… of the immune cell transcriptomes from 43 asymptomatic … differences in immune transcriptomes
between asymptomatic … In summary, whole blood transcriptomes identified individual …

Identification of host transcriptome-guided repurposable drugs for SARS-CoV-1 infections and their validation with SARS-CoV-2 infections by using the integrated …

FF Ahmed, MS Reza, MS Sarker, MS Islam… - PLoS …, 2022 - journals.plos.org
… [25] as the meta drug agents to explore few top ranked host transcriptome-guided drugs
against SARS-CoV-2 infections by molecular docking with our proposed receptor proteins. The …

Age-associated ligand-receptor interactions imputed from nasopharyngeal transcriptomes of COVID-19 patients

S Batchu, S Yu - Immunological Investigations, 2022 - Taylor & Francis
… in host response related to age, the present study imputed … SARS-COV-2. Tissue purities,
the proportion of non-immune cells in the tissue sample, of 467 nasopharyngeal transcriptome

Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19

JF Fullard, HC Lee, G Voloudakis, S Suo, B Javidfar… - Genome medicine, 2021 - Springer
… We then performed transcriptome analysis covering > 99% of SARS-CoV-2 genome and
all potential serotypes. For each brain region and donor, we included a single dissection with …

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity

Z Inde, BA Croker, C Yapp, GN Joshi, J Spetz… - Science …, 2021 - science.org
… and our current understanding of SARS-CoV-2 infection, we propose that increased expression
of ACE2 in airway and alveolar epithelial cells in infancy and old age contributes to the …

[HTML][HTML] Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine model

VD Krishna, A Chang, H Korthas, SR Var, WC Low, L Li… - bioRxiv, 2023 - ncbi.nlm.nih.gov
… Although the underlying mechanisms contributing to brain pathology are not fully understood,
we observed significant changes in the transcriptome of SARS-CoV-2 infected brains that …