… hypothesized that tissue-intrinsic changes that occur with aging may offer valuable clues. …
landscape of the aging human lung in relation to SARS-CoV-2. We find that the aging lung is …

… Studies involving the role of lung aging and senescence play an important role in understanding
the role of the multiple players involved in combating SARS-CoV-2 infection and can …

… GTEx) data to test whether lung aging is associated with transcriptional changes … lung aging
is associated with transcriptional changes in proteins that potentially interact with SARS-CoV…

… During SARS-CoV-1 infection, lung DCs from older mice displayed an impaired ability to
migrate to the draining lymph node, which negatively affected subsequent T cell priming 125 . …

… to Coronavirus Disease (COVID)-19 and more severe outcomes, although the underlying
mechanisms are understudied. The lung … Here, we investigated age-associated SARS-CoV-2 …

… We hypothesized that cell senescence, a basic aging process … To further evaluate
potential links between SARS-CoV-2 … We also monitored lung cell senescence in SARS-CoV-2–…

… Accordingly, lung ACE2 underexpression and the consequent impaired inhibition of DABK/…
lung inflammation. In mice, in vivo injection of SARS-CoV spike protein worsens acute lung …

… lung with temporally resolved immunofluorescence in mouse and human lung tissue, we
found that expression of SARS-CoV-2 … TMPRSS2 expression increased with aging in mice and …

… lesions and inflammation in the lungs became more pronounced and widespread at later
time points in the elderly. Notably, age-related differences of SARS-Cov-2 infections have also …

… The exclusion criteria comprised: (1) the average age of the … a cause of death different from
SARS-CoV-2 infection, and (4) … median age of the patients, patient’s sex, comorbidities, lung …