[HTML][HTML] Neurological sequela and disruption of neuron-glia homeostasis in SARS-CoV-2 infection

MG Savelieff, EL Feldman, AM Stino - Neurobiology of disease, 2022 - Elsevier
… of SARS-CoV-2-triggered loss of neuron-glial homeostasis. … studies of virally induced neuronal
loss, endothelial astrogliosis, … , followed by a focus on neuron-glial interactions. Lastly, we …

[HTML][HTML] Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives

G Vargas, LHM Geraldo, NG Salomão, MV Paes… - Brain, behavior, & …, 2020 - Elsevier
neuronal damage. Here, we provide an overview of these data and discuss the possible
implications of glial cells as targets of SARS-CoV… , we shed light on glial cells as possible drivers …

Neurological complications and infection mechanism of SARS-COV-2

D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
… is also expressed on glial cells and neurons of various structures, including olfactory
epitheliums, striatum, cortex, substantia nigra, as well as the brainstem, implying that SARS-CoV-2 …

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

R Martínez-Mármol, R Giordano-Santini, E Kaulich… - Science …, 2023 - science.org
… that SARS-CoV-2 infection induces fusion between neurons and between neurons and glia
… fusogen, as it is fully mimicked by the expression of the SARS-CoV-2 spike (S) protein or the …

[HTML][HTML] SARS-CoV-2 infects brain astrocytes of COVID-19 patients and impairs neuronal viability

F Crunfli, VC Carregari, FP Veras, PH Vendramini… - MedRxiv, 2021 - medrxiv.org
… secretory phenotype that reduces neuronal viability. Our data support the model in which
SARS-CoV-2 reaches the brain, infects astrocytes and consequently leads to neuronal death or …

… and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for SARS-CoV-2 impact on …

F Pistollato, M Petrillo, LA Clerbaux, G Leoni… - Reproductive …, 2022 - Elsevier
… and neuronal network … neuronal/glial models combined with emerging knowledge
described in AOPs relevant for COVID-19 could enable mechanistic understanding of SARS-CoV

[HTML][HTML] SARS-CoV-2 targets glial cells in human cortical organoids

CL McMahon, H Staples, M Gazi, R Carrion, J Hsieh - Stem Cell Reports, 2021 - cell.com
… cell-derived cortical organoids to investigate whether SARS-CoV-2 could infect brain … glial
cells and cells of the choroid plexus were preferentially targeted in our model, but not neurons

Evidence of central nervous system infection and neuroinvasive routes, as well as neurological involvement, in the lethality of SARSCoV‐2 infection

JM Liu, BH Tan, S Wu, Y Gui, JL Suo… - Journal of medical …, 2021 - Wiley Online Library
… reported that SARS-COV-2 could enter the cerebral cortex and hippocampus … SARS-CoV-2
antigen was present in neurons and glial cells along the soma and axons of infected neurons

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid analyses

A Pilotto, S Masciocchi, I Volonghi… - Clinical Infectious …, 2021 - academic.oup.com
… The present study demonstrated that SARS-CoV-2 encephalitis are associated with early
IL-8 increases and glial alterations, whereas neuronal damage markers were elevated in …

SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19

D Beckman, A Bonillas, GB Diniz, S Ott, JW Roh… - Cell reports, 2022 - cell.com
… In addition to SARS-CoV-2 N, we were able to detect SARS-CoV-2 … Taken together, our
data indicate that SARS-CoV-2 is … Viral proteins are found in both neuronal and glial cells, but …