… of the viral genome have been recognized as important factors affecting the rate of mutations.
Coronavirus disease 2019 (Covid-19) is a novel viral … The current article discusses viral …

… of the increasing SARS-CoV-2 mutations and the viral … viruses, one of which is SARS-CoV-2,
are defined by a high mutation rate, one million times higher than their host. Viral mutagenic …

… frequency of viral RNA mutations and impairs SARS-CoV-2 … -induced RNA mutagenesis
by the viral RNA-dependent RNA … complexes that contain mutagenesis products shows that …

… for the treatment of several viral diseases. We demonstrate here that Favipiravir predominantly
exerts an antiviral effect through lethal mutagenesis. The SARS-CoV RdRp complex is at …

… Lethal mutagenesis is a broad-spectrum antiviral strategy that exploits the high mutation …
many RNA viruses. A number of successful viral extinctions in cell culture using other mutagenic …

… coronavirus 2 (SARS-CoV-2) remains challenging. The virus can cause severe forms of
coronavirus disease 2019 (COVID-19) that require hospitalization. Remdesivir (RDV) targets the …

… the generation of viral mutations promoted by SARS-CoV-2 persistence in senescent
cells. … with viral mutagenesis, by conducting a bioinformatic analysis, we found that viruses …

… Efficacy, affordability, and ease of access (eg, oral route) of antiviral drugs are essential
for the prevention and control of epidemic situations caused by viruses such as SARS-CoV-2. …

… in virus titer (Figure 1A); we failed to detect any mutagenesis above background in the
FAV-treated cultures. We also examined toxicity of these analogs in the target A549-hACE-2 cells (…

… The TMD of the SARS CoV spike protein consists of three … mutagenesis study of the aromatic
domain of SARS CoV S and … SARS CoV virus S protein plays a crucial role in the entry of …