[HTML][HTML] The spike protein of SARS-CoV—a target for vaccine and therapeutic development

L Du, Y He, Y Zhou, S Liu, BJ Zheng… - Nature Reviews …, 2009 - nature.com
… on the spike (S) protein of severe acute respiratory syndrome-coronavirus (SARS-CoV) as a
… for the development of vaccines and therapeutics for the prevention and treatment of SARS. …

Structure of SARS-CoV-2 spike protein

J Zhang, T Xiao, Y Cai, B Chen - Current opinion in virology, 2021 - Elsevier
… relationships of viral proteins and relevant host factors. The trimeric spike (S) protein of the
virus … of the SARS-CoV-2 S protein and discuss the implications for vaccines and therapeutics. …

Human SARS CoV‐2 spike protein mutations

L Guruprasad - Proteins: Structure, Function, and Bioinformatics, 2021 - Wiley Online Library
… in 8155 proteins among 10333 human SARS-CoV-2 spike protein sequences analyzed in
… for all the spike proteins. The mutation sites are distributed over whole length of the protein

[HTML][HTML] Domains and functions of spike protein in Sars-Cov-2 in the context of vaccine design

X Xia - Viruses, 2021 - mdpi.com
… The integration of structure and function of SARS-2-S in this review should enhance our …
for the spike protein to be frequently featured in the conspiracy theory claiming that SARS-CoV-2 …

[PDF][PDF] Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant

L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch… - Cell, 2020 - cell.com
The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide,
reaching near fixation in a matter of months. Here we show that D614G was more infectious …

Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development

SK Samrat, AM Tharappel, Z Li, H Li - Virus research, 2020 - Elsevier
… of the coronavirus is the club-shaped spike protein projecting … vaccine-induced antibodies
against SARS-CoV-2 may bind to … Spike protein have been found in circulating clinical SARS-…

[HTML][HTML] SARS-CoV-2 spike protein interacts with and activates TLR41

Y Zhao, M Kuang, J Li, L Zhu, Z Jia, X Guo, Y Hu… - Cell research, 2021 - nature.com
… was activated by SARS-CoV-2, we hypothesized that spike protein could activate … SARS-CoV-2
spike proteins are high quality antigens. To this end, we purified the trimeric spike protein

[HTML][HTML] Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms

A Ali, R Vijayan - Scientific reports, 2020 - nature.com
… Hence, there are noteworthy differences between how the two viral spike proteins interact …
SARS-CoV-2 spike protein could be associated with a higher binding affinity of SARS-CoV-2. …

[HTML][HTML] Spike protein of SARS-CoV-2 variants: a brief review and practical implications

KL Candido, CR Eich, LO de Fariña… - Brazilian Journal of …, 2022 - Springer
… the spike (S) protein gene sequence that leads to structural alterations in the predicted protein,
… vaccines, emphasizing the different spike protein structures of SARS-CoV-2 and updating …

Structural impact on SARS-CoV-2 spike protein by D614G substitution

J Zhang, Y Cai, T Xiao, J Lu, H Peng, SM Sterling… - Science, 2021 - science.org
… respiratory syndrome coronavirus 2 (SARS-CoV-2) with particular focus on the spike protein.
… Structural and biochemical studies on a full-length G614 spike trimer showed that there are …