… ; and (iii) systematically identify, assess, and map the risk structure of individual research
programs or entire portfolios to foster data-enabled and risk-integrative decision-making. …

… , Lever, that systematically maps metazoan DNA regulatory motifs or motif combinations
to sets of genes. Lever assesses whether the motifs are enriched in cis-regulatory modules (…

… This paper offers a systematic approach to analyzing the elements, linkages, and underlying
logic of policy designs. The approach integrates and applies multiple concepts from the …

Background We aimed to determine the strength of evidence on the effectiveness of
legislative and regulatory policy levers in creating incentives for organizations to improve …

… regulatory programs during cell-type maturation. We also found lineage-common regulatory
programs … In particular, we identified Xbp1 as an evolutionarily conserved regulator of cell-…

… regulatory programs governing diverse aspects of RNA biology remain largely uncharacterized.
Understanding the functional roles of RNA cis-regulatory elements … regulatory programs. …

… have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity
tests. The multiple mechanisms associated with acute systemic toxicity preclude a single cell- …

… binding sites, are associated with genomic regulatory activity [8, 26]. To assess the
endogenous chromatin features of the identified regulatory elements, we analyzed the available …

… This study provides novel insights into the transcriptional regulatory networks of
pluripotent cells. Our results suggest that this systematic approach can be broadly applied to …

… We systematically identified regulatory elements of HERVs based on publicly available
datasets of ChIP-Seq of 97 TFs. Clustering analysis showed that HERV/LTRs can be grouped by …