[HTML][HTML] Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism

NL Pessoa, AA Bentes, AL de Carvalho… - Virology Journal, 2021 - Springer
… To our knowledge, this is the first report of a SARS-CoV-2 caused hepatitis in a male child
that has the tlr-7 Gln11Leu rs 179008, which could impair an efficient initial immune response. …

[HTML][HTML] Innate immune recognition against SARS-CoV-2

T Yamada, A Takaoka - Inflammation and Regeneration, 2023 - Springer
… with TLR3 and … SARS-CoV-2 infection in Calu-3/MRC-5 multicellular spheroids [58].
Further studies are needed to clarify what PAMPs are directly sensed by TLRs during SARS-CoV-2 …

[HTML][HTML] Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients

MCS Menezes, ADM Veiga, T Martins de Lima… - Scientific reports, 2021 - nature.com
… This study explored the impact that SARS-CoV-2 infection could have in the peripheral blood
… Here, we demonstrate that lower expression of TLR-3 and an enhanced expression of TLR-…

[HTML][HTML] Immunobiotic lactobacilli improve resistance of respiratory epithelial cells to SARS-CoV-2 infection

MA Islam, L Albarracin, M Tomokiyo, JC Valdez… - Pathogens, 2021 - mdpi.com
… Previously, we reported that immunomodulatory lactobacilli, nasally administered, beneficially
regulated the lung antiviral innate immune response induced by Toll-like receptor 3 (TLR3

SARSCoV‐2 NSP7 inhibits type I and III IFN production by targeting the RIG‐I/MDA5, TRIF, and STING signaling pathways

J Deng, Y Zheng, SN Zheng, ML Nan… - Journal of Medical …, 2023 - Wiley Online Library
… Viral dsRNA can be also recognized by endosomal Toll-like receptor 3 (TLR3), which can
evoke an IFN response via recruitment of TRIF. In addition, the cytoplasmic dsDNA sensor …

[HTML][HTML] Innate immunity: the first line of defense against SARS-CoV-2

MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
… other TLRs in SARS-CoV-2 infection has not been as conclusively studied in vitro and in vivo.
In the context of SARS-CoV, the TLR3 … to date have linked TLR3 with SARS-CoV-2 sensing …

[HTML][HTML] Protective role of Toll-like receptor 3-induced type I interferon in murine coronavirus infection of macrophages

L Mazaleuskaya, R Veltrop, N Ikpeze, J Martin-Garcia… - Viruses, 2012 - mdpi.com
… infected with severe acute respiratory syndrome (SARS)-CoV [10]. The adaptive immune
response that occurs during CoV infection is well characterized [3,5], but our understanding of …

[HTML][HTML] Protective effects of lactoferrin against SARS-CoV-2 infection in vitro

C Salaris, M Scarpa, M Elli, A Bertolini, S Guglielmetti… - Nutrients, 2021 - mdpi.com
… expression of toll-like receptor 3 (TLR3) and 7 (TLR7), which are pattern recognition receptors
involved in sensing of RNA viruses (Figure 2B), and of interferon regulatory factor 3 (IRF3) …

[HTML][HTML] Host cell-intrinsic innate immune recognition of SARS-CoV-2

EA Madden, MS Diamond - Current opinion in virology, 2022 - Elsevier
… In this review, we highlight the components of cell-based recognition of SARS-CoV-2 …
TLR signaling can also promote nuclear translocation of the transcription factors IRF-3 and …

[HTML][HTML] COVID-19 subunit vaccine with a combination of TLR1/2 and TLR3 agonists induces robust and protective immunity

SK Jeong, YK Heo, JH Jeong, SJ Ham, JS Yum… - Vaccines, 2021 - mdpi.com
… whether a combination of toll-like receptor (TLR)1/2 and TLR3 agonists (L-pampo) can be
a potent adjuvant for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subunit …