Structure and function differences in the prelimbic cortex to basolateral amygdala circuit mediate trait vulnerability in a novel model of acute social defeat stress in …

YS Grossman, C Fillinger, A Manganaro… - …, 2022 - nature.com
… To examine differences in PL→BLA activation during stress as a biomarker for trait vulnerability,
our first objective was to develop and validate an acute stressor that identifies resilient …

Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar …

A Versace, WK Thompson, D Zhou, JRC Almeida… - Biological …, 2010 - Elsevier
amygdala-OFC FC to emotional stimuli in BD. Only one study examined FC–FA relationships
in neural circuitry … in FA and FC between amygdala and pericingulate gyrus during happy …

Neurobiological programming of early life stress: functional development of amygdala-prefrontal circuitry and vulnerability for stress-related psychopathology

MR VanTieghem, N Tottenham - Behavioral neurobiology of PTSD, 2018 - Springer
circuitry across development: (1) heightened amygdala reactivity and (2) altered amygdala-…
Next, we will discuss how developmental changes in amygdala-prefrontal circuitry predict …

Fear-conditioning mechanisms associated with trait vulnerability to anxiety in humans

I Indovina, TW Robbins, AO Núñez-Elizalde, BD Dunn… - Neuron, 2011 - cell.com
… with elevated trait vulnerability to anxiety. We hypothesized that amygdala responsivity to
phasic … of individual variability associated with trait vulnerability to anxiety, primarily influencing …

The adaptive threat bias in anxiety: amygdala–dorsomedial prefrontal cortex coupling and aversive amplification

OJ Robinson, DR Charney, C Overstreet, K Vytal… - Neuroimage, 2012 - Elsevier
… Increased DMPFC–amygdala coupling was … trait anxiety and may thus drive anxiety
disorder vulnerability. ► May be the human homologue of the rodent prelimbic–amygdala circuit. …

Effect of prefrontal cortex stimulation on regulation of amygdala response to threat in individuals with trait anxiety: a randomized clinical trial

M Ironside, M Browning, TL Ansari, CJ Harvey… - JAMA …, 2019 - jamanetwork.com
… in prefrontal cortical control regions inhibits amygdala responses to threat. … amygdala circuit
to perform a causal test of this hypothesis in a sample population of individuals with high trait

Trait anxiety mediated by amygdala serotonin transporter in the common marmoset

SKL Quah, L McIver, AC Roberts… - Journal of …, 2020 - Soc Neuroscience
circuitry is extensively modulated by serotonin. Here, to understand why some people may
be more vulnerable … regulation circuitry may underlie individual differences in trait anxiety …

Amygdala hyperactivation and prefrontal hypoactivation in subjects with cognitive vulnerability to depression

M Zhong, X Wang, J Xiao, J Yi, X Zhu, J Liao… - Biological …, 2011 - Elsevier
Vulnerability to depression is typically conceptualized as a … vulnerability factors, the
notion of cognitive vulnerability (CV) … CV could be defined as a trait-like tendency to interpret …

Prefrontal cortex reactivity underlies trait vulnerability to chronic social defeat stress

S Kumar, R Hultman, D Hughes, N Michel… - Nature …, 2014 - nature.com
circuits can therefore dramatically affect vulnerability to these illnesses. Here we identify neural
circuit … cortex (PFC) control of amygdala activity predicts stress susceptibility in individual …

Age-related reduced prefrontal-amygdala structural connectivity is associated with lower trait anxiety.

D Clewett, S Bachman, M Mather - Neuropsychology, 2014 - psycnet.apa.org
trait anxiety and right amygdala-vPFC FA (p = .01). Conclusion: These findings argue against
the notion that greater amygdala… a regulatory circuit, we instead found that amygdala-vPFC …