Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

B Miller, A Silverstein, M Flores, K Cao, H Kumagai… - Scientific Reports, 2021 - nature.com
… How SARS-CoV-2 modifies the mitochondrial transcriptomeresponse evasion. In the
following analyses, we assessed the effect of SARS-CoV-2 on the mitochondrial transcriptome by …

Comparative transcriptome analysis reveals the intensive early stage responses of host cells to SARS-CoV-2 infection

J Sun, F Ye, A Wu, R Yang, M Pan, J Sheng… - Frontiers in …, 2020 - frontiersin.org
… rapid growth of the virus was accompanied by an early intensive response of host …
response to SARS-CoV-2, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV

Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection

M Salgado-Albarrán, EI Navarro-Delgado… - NPJ systems biology …, 2021 - nature.com
… ; however, such changes are not fully described for SARS-CoV-2. In … transcriptomes obtained
from cell lines infected with MERS-CoV, SARS-CoV, and SARS-CoV-2, and from COVID-19

Comparative transcriptome analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to identify potential pathways for drug repurposing

P Krishnamoorthy, AS Raj, S Roy, NS Kumar… - Computers in biology …, 2021 - Elsevier
… of COVID-19. In this study, first, we explored the host transcriptome responses upon
SARS-CoV-2 infection with those of the two previous outbreak-related pathogenic coronaviruses, …

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

D Butler, C Mozsary, C Meydan, J Foox… - Nature …, 2021 - nature.com
Coronavirus 2 (SARS-CoV-2) killed over a million people, including >25,000 in New York City
(NYC) alone. The COVID-19 pandemic caused by SARS-CoV-2 … for SARS-CoV-2 infection …

A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome

D Kim, S Kim, J Park, HR Chang, J Chang… - Nature …, 2021 - nature.com
transcriptome of SARS-CoV-2 for various time points after infecting human cells. Intriguingly,
substantial amount of SARS-CoV-2 … RNAs, the SARS-CoV-2 translatome may be regulated …

… samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2

ABMMK Islam, MAAK Khan, R Ahmed… - Journal of translational …, 2021 - Springer
responses of hosts play an enormous role. In this context, we aimed to discover the host
transcriptome response upon SARS-CoV-2 … samples of four COVID-19 positive individuals. …

Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus

S Li, W Liu, Y Chen, L Wang, W An, X An… - Briefings in …, 2021 - academic.oup.com
… from COVID-19 patients. In summary, this study uncovered the transcriptome of a SARS-CoV-2-related
coronavirus … for CEP as a promising therapeutic option for SARS-CoV-2 infection. …

Network analysis and transcriptome profiling identify autophagic and mitochondrial dysfunctions in SARS-CoV-2 infection

K Singh, YC Chen, S Hassanzadeh, K Han… - Frontiers in …, 2021 - frontiersin.org
2 (SARS-CoV-2) infection will help delineate biological processes underlying viral … signaling
genes in response to all three SARS-CoV-2, MERS-CoV, or influenza A virus (IAV) infections…

Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2

S Di Giorgio, F Martignano, MG Torcia, G Mattiuz… - Science …, 2020 - science.org
… could be involved in human host responses to SARS-CoV-2 infections, we started from …
with COVID-19. While transcriptomic data for all samples could be aligned to the SARS-CoV-2