[HTML][HTML] Targeting inflammation and immunosenescence to improve vaccine responses in the elderly

B Pereira, XN Xu, AN Akbar - Frontiers in immunology, 2020 - frontiersin.org
… in the elderly include the use of higher vaccine doses or alternative routes of vaccination
enhancing vaccine responses in older adults, including the use of anti-inflammatory drugs …

Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses

SN Crooke, IG Ovsyannikova, GA Poland… - Experimental …, 2019 - Elsevier
… to learn regarding immunosenescence, systems-level studies of vaccine responses have
been highly informative and will guide the development of new vaccine candidates, novel …

A systems biology approach to the effect of aging, immunosenescence and vaccine response

GA Poland, IG Ovsyannikova, RB Kennedy… - Current opinion in …, 2014 - Elsevier
… cellular responses to vaccineresponses to common vaccines. We highlight how researchers
are approaching a deeper understanding of immunosenescence and vaccine response

Immunosenescence and vaccine failure in the elderly

B Grubeck-Loebenstein, S Della Bella, AM Iorio… - Aging clinical and …, 2009 - Springer
… are being developed, such as intradermal and high-dose vaccines for influenza, to improve
… of immunosenescence to identify patients who may have impaired responses to vaccination, …

[HTML][HTML] Immunosenescence and human vaccine immune responses

SN Crooke, IG Ovsyannikova, GA Poland… - Immunity & …, 2019 - Springer
… of immunosenescence on … immunosenescence can guide vaccine research efforts in this
population. We also provide an outlook on personalized vaccine development (ie, vaccines

Immunosenescence and vaccine failure in the elderly: strategies for improving response

D Boraschi, P Italiani - Immunology Letters, 2014 - Elsevier
… Since the understanding of the mechanistic basis of immune senescence is still partial,
no current vaccination strategy is based on such knowledge and the approaches have been …

Immunosenescence: implications for response to infection and vaccination in older people

A Pera, C Campos, N López, F Hassouneh, C Alonso… - Maturitas, 2015 - Elsevier
… of latent CMV infection in immunosenescence and its consequences in sepsis and response
to vaccination. We analyse the effect of gender on immunosenescence and how other age-…

[HTML][HTML] Understanding immunosenescence to improve responses to vaccines

JJ Goronzy, CM Weyand - Nature immunology, 2013 - nature.com
… In the older adult, the benefits of vaccination to prevent infectious disease are … 'immunosenescence',
results from the progressive deterioration of innate and adaptive immune responses. …

Aging of the immune system: focus on inflammation and vaccination

M Pinti, V Appay, J Campisi, D Frasca… - European journal of …, 2016 - Wiley Online Library
Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …

Understanding immunosenescence and its impact on vaccination of older adults

JC Allen, FR Toapanta, W Chen, SM Tennant - Vaccine, 2020 - Elsevier
… Although vaccination is the most logical solution in preventing infectious diseases, primary
vaccine responses … This is presumably attributed to immunosenescence, a term that describes …