An overview of viral mutagenesis and the impact on pathogenesis of SARS-CoV-2 variants

MZI Khan, A Nazli, H Al-Furas, MI Asad, I Ajmal… - Frontiers in …, 2022 - frontiersin.org
… Coronavirus disease 2019 (Covid-19) is a novel viral disease … The current article discusses
viral mutations and their impact … -2), its mutations, pathogenesis, and treatment strategies are …

Role of free radicals in viral pathogenesis and mutation

T Akaike - Reviews in medical virology, 2001 - Wiley Online Library
… of viral pathogenesis almost a decade ago we sought to identify eOH generation in influenza
virus-… Therefore, we may expect such chemical mutagenesis in DNA viruses, bacteria and …

Virus mutators and antimutators: roles in evolution, pathogenesis and emergence

LM Mansky, KS Cunningham - Trends in Genetics, 2000 - cell.com
… about such genetic variants in viruses that infect humans and threaten … viral infection (particularly
in the case of RNA viruses) could play a pivotal role in virus evolution, pathogenesis

Quasispecies and its impact on viral hepatitis

E Domingo, J Gomez - Virus research, 2007 - Elsevier
viral evolution that can affect viral pathogenesis. Relevant evolutionary events include the
generation of minority virus … to viral extinction through enhanced mutagenesis (virus entry into …

Impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformation

ML Gatza, C Chandhasin, RI Ducu… - … mutagenesis, 2005 - Wiley Online Library
… been explicitly linked to the expression of oncoproteins encoded by these viruses. This
review discusses mechanisms utilized by these viral oncoproteins, Tax, HBx, and E6/E7, to …

Targeted DNA mutagenesis for the cure of chronic viral infections

JT Schiffer, M Aubert, ND Weber, E Mintzer… - Journal of …, 2012 - Am Soc Microbiol
… in certain plant-pathogenic species of Xanthomonas (… The role that this process plays in
bacterial pathogenesis in … and repair ultimately lead to mutagenic NHEJ pathways. In the …

Influence of mutagenesis and viral load on the sustained low-level replication of an RNA virus

C Perales, R Agudo, SC Manrubia… - Journal of molecular …, 2011 - Elsevier
… of the virus either towards survival through selection of mutagen-… involving the mutagenesis
of foot-and-mouth disease virus (… effect of R-mediated mutagenesis on the selection of FMDV …

Viral quasispecies: dynamics, interactions, and pathogenesis

E Domingo, C Escarmís, L Menéndez-Arias… - … and evolution of viruses, 2008 - Elsevier
… ” in this chapter, we summarize our current view on the mechanisms that underlie virus
extinction through lethal mutagenesis based on experimental results, and the main challenges …

Mutagenesis-mediated virus extinction: virus-dependent effect of viral load on sensitivity to lethal defection

H Moreno, H Tejero, JC De la Torre, E Domingo… - PloS one, 2012 - journals.plos.org
… extinction mediated by enhanced mutation rates during viralViral load and virus fitness are
known to influence virus extinction. … of several RNA viruses under enhanced mutagenesis. …

Viral fitness: history and relevance for viral pathogenesis and antiviral interventions

E Domingo, AI de Avila, I Gallego… - Pathogens and …, 2019 - academic.oup.com
virus apply to viruses that follow a different replicative cycle; (iv) the recognition that viral
fitness per se is relevant to viral pathogenesis and viral … impelled by the mutagenic activity but it …