Interactions of SARS-CoV-2 with the blood–brain barrier

MA Erickson, EM Rhea, RC Knopp… - International Journal of …, 2021 - mdpi.com
… by PCR but it was not determined whether this was replicative virus or whether the mice had
brain pathology [70]. In summary, there is evidence of brain SARS-CoV-2 entry and infection…

[HTML][HTML] What SARS-CoV-2 does to our brains

T Aschman, R Mothes, FL Heppner, H Radbruch - Immunity, 2022 - cell.com
… observed after SARS-CoV-2 infection could be (1) directly caused by the virus infecting brain
cells, (2) indirectly by our body’s local or systemic immune response toward the virus, (3) by …

Does SARSCov‐2 invade the brain? Translational lessons from animal models

S Natoli, V Oliveira, P Calabresi… - European journal of …, 2020 - Wiley Online Library
… Overall, their results showed that, in this model, SARS-CoV primarily entered the brain via …
Neurons are a highly susceptible target for SARS-CoV. The virus enters the brain primarily via …

SARS-CoV-2: olfaction, brain infection, and the urgent need for clinical samples allowing earlier virus detection

R Butowt, K Bilinska - ACS chemical neuroscience, 2020 - ACS Publications
… (7) The results from transgenic hACE2 mice indicate that SARS-CoV probably uses … in the
brain and this can also be true for SARS-CoV-2. It is known for other viruses, eg, rabies virus, …

Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

I Rutkai, MG Mayer, LM Hellmers, B Ning… - Nature …, 2022 - nature.com
… assessment of brain pathology associated with SARS-CoV-2 … This work reveals
neuroinflammation, brain hypoxia, … with rare infection of brain vasculature in SARS-CoV-2 infected …

SARS-CoV-2: is there neuroinvasion?

C McQuaid, M Brady, R Deane - Fluids and Barriers of the CNS, 2021 - Springer
… The aim of the review is to provide the general readership with the breadth of information
on the virus, the distribution of its main host cell receptor, the brain vascular barriers, and the …

SARS-CoV-2 infects human neural progenitor cells and brain organoids

BZ Zhang, H Chu, S Han, H Shuai, J Deng, Y Hu… - Cell research, 2020 - nature.com
… that SARS-CoV-2 RNA could be detected in brain biopsies in … the potential for viral infections
in the human brain. To date, … from infected brain organoids to evaluate SARS-CoV-2 virus

Neurological complications associated with the blood-brain barrier damage induced by the inflammatory response during SARS-CoV-2 infection

I Alquisiras-Burgos, I Peralta-Arrieta… - Molecular …, 2021 - Springer
viral particles and viral genome sequences of SARS-CoV have been detected in the cytoplasm
of neurons of the brain… This evidence suggests that SARS-CoV-2 crosses the BBB as well …

[HTML][HTML] SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids

L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul… - Cell stem cell, 2020 - cell.com
… -derived brain organoids to examine SARS-CoV-2 neurotropism. We find expression of viral
… We challenge organoids with SARS-CoV-2 spike pseudovirus and live virus to demonstrate …

Neurological complications and infection mechanism of SARS-COV-2

D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
viruses can enter the brain via a weakened blood–brain barrier (BBB). Even though not all
patients test positive for SARS-CoV-… common as a result of viral infection. The pathogenesis of …