The tumour microenvironment contributes greatly to the response of tumour cells. It consists
of chemical gradients, for example of oxygen and nutrients. However, a physical …

Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …

Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …

Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …

Results Cell plasticity allows adaptative strategies for cancer cells to survive or eventually
escape from tumoral environment through modification of the microenvironment–cell …

The importance of the tumor microenvironment in cancer progression is indisputable, yet a
key component of the microenvironment—biomechanical forces—remains poorly …

The role of mechanical properties in cancer disease and inflammation is still
underinvestigated and even ignored in many oncological and immunological reviews. In …

BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …

The study of physical and mechanical features of cancer cells, or cancer cell
mechanobiology, is a new frontier in cancer research. Such studies may enhance our …