The malignancy of tumors depends on the biomechanical properties of cancer cells and
their microenvironment, which enable cancer cells to migrate through the connective tissue …

The physical cues of tumor microenvironment (TME) contribute greatly to the initiation and
progression of cancer. Tumor tissues usually become stiffer than healthy tissues with more …

Cellular motility and invasion in connective tissue is a basic and fundamental process during
normal physiological tissue developments and assemblies, prevention of inflammation after …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Background Metastasis refers to the spread of cancer cells from a primary tumor to other
parts of the body via the lymphatic system and bloodstream. With tremendous effort over the …

Since the crucial role of the microenvironment has been highlighted, many studies have
been focused on the role of biomechanics in cancer cell growth and the invasion of the …

The role of tumor microenvironment in cancer progression is gaining significant attention. It
is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells …

Results Cell plasticity allows adaptative strategies for cancer cells to survive or eventually
escape from tumoral environment through modification of the microenvironment–cell …

The function of biological tissues in health and disease is regulated at cellular level and is
highly influenced by the physical microenvironment, through the interaction of forces …

The cancer cells obtain their invasion potential not only by genetic mutations, but also by
changing their cellular biophysical and biomechanical features and adapting to the …