Metabolism and mechanics are intrinsically intertwined. External forces, sensed through the
cytoskeleton or distortion of the cell and organelles, induce metabolic changes in the cell …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

Mechanical forces play a fundamental role in cellular dynamics from the molecular level to
the establishment of complex heterogeneity in somatic and stem cells. Here, we highlight the …

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all
physiopathological processes of tissues, mechanical forces impact the structure and function …

With the recent revolution in Molecular Biology and the deciphering of the Human Genome,
understanding of the building blocks that comprise living systems has advanced rapidly. We …

Cellular responses to mechanical forces are crucial in embryonic development and adult
physiology, and are involved in numerous diseases, including atherosclerosis …

All cells exist within the context of a three-dimensional microenvironment in which they are
exposed to mechanical and physical cues. These cues can be disrupted through …

The role of mechanical signals in the proper functioning of organisms is increasingly
recognised, and every cell senses physical forces and responds to them. These forces are …

All living organisms experience force (Figure 1). These forces exist at the nanoscale level
through to the tissue level and range from piconewtons upward to several orders of …

Mechanical force is present in all aspects of living systems. It affects the conformation of
molecules, the shape of cells, and the morphology of tissues. All of these are crucial in …