Solid tumors are characterized by an abnormal stroma that contributes to the development of
biomechanical abnormalities in the tumor microenvironment. In particular, these …

Metastatic cells migrate from the site of the primary tumor, through the stroma, into the blood
and lymphatic vessels, finally colonizing various other tissues to form secondary tumors …

Several physico-chemical properties of the tumour microenvironment (TME) are
dysregulated during tumour progression, such as tissue stiffness, extracellular pH and …

Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

Tumors are not merely masses of neoplastic cells but complex tissues composed of cellular
and noncellular elements. This review provides recent data on the main components of a …

Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

Disseminated metastatic cancer cells represent one of the most relevant causes of disease
relapse and associated death for cancer patients, and a therapeutic target of the highest …

Cancer cells exist in a mechanically and chemically heterogeneous microenvironment
which undergoes dynamic changes throughout neoplastic progression. During metastasis …

Biomechanical regulation of tumor phenotypes have been noted for several decades, yet the
function of mechanics in the co-evolution of the tumor epithelium and altered cancer …

Malignant transformation, though primarily driven by genetic mutations in cells, is also
accompanied by specific changes in cellular and extra-cellular mechanical properties such …