Cells within tissues are continuously exposed to physical forces including hydrostatic
pressure, shear stress, and compression and tension forces. Cells dynamically adapt to …

Cells in tissues are mechanically coupled both to the ECM and neighboring cells, but the
coordination and interdependency of forces sustained at cell-ECM and cell–cell adhesions …

Oncologists often diagnose cancer based on a change of tissue stiffness sensed by
palpation, yet cancer researchers generally focus on biochemical signaling mechanisms …

In cancer, solid stresses impede the delivery of therapeutics to tumours and the trafficking
and tumour infiltration of immune cells. Understanding such consequences and the origin of …

Cells respond to both chemical and mechanical cues present within their microenvironment.
Various mechanical signals are detected by and transmitted to the cells through …

Mechanical rigidity in the tumor microenvironment is associated with a high risk of tumor
formation and aggressiveness. Adhesion-based signaling driven by a rigid …

The tumor microenvironment (TME) is gaining increasing attention in oncology, as it is
recognized to be functionally important during tumor development and progression. Tumors …

Mechanical factors in the tumor microenvironment play an important role in response to a
variety of cellular activities in cancer cells. Here, we utilized polyacrylamide hydrogels with …

Tumors generate physical forces during growth and progression. These physical forces are
able to compress blood and lymphatic vessels, reducing perfusion rates and creating …

While significant advances have been made toward revealing the molecular mechanisms
that influence breast cancer progression, much less is known about the associated cellular …