Close interactions between cancer cells and cancer-associated fibroblasts (CAF) have
repeatedly been reported to support tumor progression. Yet, targeting CAFs has so far failed …

The prognosis for patients with cancers known for a highly activated stromal reaction,
including diffuse‐type (scirrhous) gastric cancer, consensus molecular subtype 4 (CMS4) …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

Despite marked development in cancer therapies during recent decades, the prognosis for
advanced cancer remains poor. The conventional tumor–cell‐centric view of cancer can …

Cancer microenvironment is created not only by malignant epithelial cells, but also by
several kinds of stromal cells. Since Paget proposed the “seed and soil” hypothesis, the …

Abstract Cancer-associated fibroblasts (CAFs), as a central component of the tumor
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …

Cancer associated fibroblasts (CAFs) are the most abundant stromal cell-type in solid tumor-
microenvironment (TME) and have emerged as key player in tumor progression. CAFs …

Simple Summary Cancer-associated fibroblasts (CAFs) are key players in the tumor
microenvironment. They are responsible for potentiating growth and metastasis through …

Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …