K Kong, M Guo, Y Liu, J Zheng - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
As a common gastrointestinal tumor, the incidence of pancreatic cancer has been increasing in recent years. The disease shows multi-gene, multi-step complex evolution from …
Background Relevant preclinical models that recapitulate the key features of human pancreatic ductal adenocarcinoma (PDAC) are needed in order to provide biologically …
Pancreatic cancer (PC) is anticipated to be second only to lung cancer as the leading cause of cancer-related deaths in the United States by 2030. Surgery remains the only potentially …
Y Ding, JD Cravero, K Adrian, P Grippo - Pancreas, 2010 - journals.lww.com
In the last 10 years, there has been a relative explosion of new rodent systems that recapitulate both genetic and cellular lesions that lead to the development of pancreatic …
The past several decades have seen great effort devoted to mimicking the key features of pancreatic ductal adenocarcinoma (PDAC) in animals and have produced 2 robust models …
Pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease despite tremendous scientific efforts. Numerous trials have failed to improve the outcome on this …
EK Colvin, CJ Scarlett - Seminars in cell & developmental biology, 2014 - Elsevier
Pancreatic cancer is an inherently aggressive disease with an extremely poor prognosis and lack of effective treatments. Over the past few decades, much has been uncovered regarding …
BD Krempley, HY Kenneth - Chinese clinical oncology, 2017 - cco.amegroups.org
Unlike many other cancers, pancreatic ductal adenocarcinoma (PDAC) has seen only incremental improvement in mortality despite significant advances in our understanding of …
M Herreros-Villanueva, E Hijona, A Cosme… - World journal of …, 2012 - ncbi.nlm.nih.gov
Pancreatic cancer is one of the most lethal of human malignancies ranking 4th among cancer-related death in the western world and in the United States, and potent therapeutic …