[PDF][PDF] SnapShot: cancer-associated fibroblasts

D Park, E Sahai, A Rullan - Cell, 2020 - cell.com
Cancer-associated fibroblasts (CAFs) are an integral component of the tumor
microenvironment and have both tumor-promoting and tumor-suppressive functions. This …

Cancer-associated fibroblasts: versatile players in the tumor microenvironment

D Ganguly, R Chandra, J Karalis, M Teke, T Aguilera… - Cancers, 2020 - mdpi.com
Simple Summary Cancer-associated fibroblasts (CAFs) are key players in the tumor
microenvironment. They are responsible for potentiating growth and metastasis through …

Cancer-associated fibroblasts: understanding their heterogeneity

K Louault, RR Li, YA DeClerck - Cancers, 2020 - mdpi.com
Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …

Cancer-associated fibroblasts: tumorigenicity and targeting for cancer therapy

RA Glabman, PL Choyke, N Sato - Cancers, 2022 - mdpi.com
Simple Summary Cancer-associated fibroblasts (CAFs) are found in the tumor
microenvironment and exhibit several protumorigenic functions. Preclinical studies suggest …

A framework for advancing our understanding of cancer-associated fibroblasts

E Sahai, I Astsaturov, E Cukierman… - Nature Reviews …, 2020 - nature.com
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

Clinical and therapeutic relevance of cancer-associated fibroblasts

Y Chen, KM McAndrews, R Kalluri - Nature reviews Clinical oncology, 2021 - nature.com
Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

H Zhang, X Yue, Z Chen, C Liu, W Wu, N Zhang, Z Liu… - Molecular Cancer, 2023 - Springer
Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Cancer-associated fibroblasts: how do they contribute to metastasis?

MQ Kwa, KM Herum, C Brakebusch - Clinical & experimental metastasis, 2019 - Springer
Cancer-associated fibroblasts (CAFs) are activated fibroblasts in the tumor
microenvironment. They are one of the most prominent cell types in the stroma and produce …

Cancer-associated fibroblasts—heroes or villains?

KA Gieniec, LM Butler, DL Worthley… - British journal of cancer, 2019 - nature.com
Cancer-associated fibroblasts (CAFs) were originally presumed to represent a
homogeneous population uniformly driving tumorigenesis, united by their morphology and …

The role of cancer-associated fibroblasts in tumor progression

RS Joshi, SS Kanugula, S Sudhir, MP Pereira, S Jain… - Cancers, 2021 - mdpi.com
Simple Summary As our knowledge of cancer as a complex organ comprising tumor cells as
well as surrounding cells within the microenvironment continues to grow, it is imperative to …