Pancreatic Ductal Adenocarcinoma: Preclinical in vitro and ex vivo Models
B Gündel, X Liu, M Löhr, R Heuchel - Frontiers in cell and …, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is one of the most overlooked cancers despite its
dismal median survival time of 6 months. The biggest challenges in improving patient …
dismal median survival time of 6 months. The biggest challenges in improving patient …
A Novel Scaffold-Based Hybrid Multicellular Model for Pancreatic Ductal Adenocarcinoma—Toward a Better Mimicry of the in vivo Tumor Microenvironment
With a very low survival rate, pancreatic ductal adenocarcinoma (PDAC) is a deadly
disease. This has been primarily attributed to (i) its late diagnosis and (ii) its high resistance …
disease. This has been primarily attributed to (i) its late diagnosis and (ii) its high resistance …
[HTML][HTML] Preclinical models of pancreatic ductal adenocarcinoma
BD Krempley, HY Kenneth - Chinese clinical oncology, 2017 - cco.amegroups.org
Unlike many other cancers, pancreatic ductal adenocarcinoma (PDAC) has seen only
incremental improvement in mortality despite significant advances in our understanding of …
incremental improvement in mortality despite significant advances in our understanding of …
Novel methods for in vitro modeling of pancreatic cancer reveal important aspects for successful primary cell culture
L Ehlen, J Arndt, D Treue, P Bischoff, FN Loch… - BMC cancer, 2020 - Springer
Background Pancreatic cancer remains a fatal disease. Experimental systems are needed
for personalized treatment strategies, drug testing and to further understand tumor biology …
for personalized treatment strategies, drug testing and to further understand tumor biology …
[HTML][HTML] Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models
MA Heinrich, AMRH Mostafa, JP Morton… - Advanced drug delivery …, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
Preclinical models of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDA) is one of the most difficult human malignancies to
treat. The 5‐year survival rate of PDA patients is 7% and PDA is predicted to become the …
treat. The 5‐year survival rate of PDA patients is 7% and PDA is predicted to become the …
Modelling the micro-and macro-environment of pancreatic cancer: from patients to pre-clinical models and back
EG Lloyd, JA Henríquez, G Biffi - Disease Models & …, 2024 - journals.biologists.com
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with very low survival
rates. Over the past 50 years, improvements in PDAC survival have significantly lagged …
rates. Over the past 50 years, improvements in PDAC survival have significantly lagged …
[HTML][HTML] Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation
SJ Coleman, J Watt, P Arumugam… - World journal of …, 2014 - ncbi.nlm.nih.gov
Pancreatic cancer carries a terrible prognosis, as the fourth most common cause of cancer
death in the Western world. There is clearly a need for new therapies to treat this disease …
death in the Western world. There is clearly a need for new therapies to treat this disease …
Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma
S Misra, CF Moro, M Del Chiaro, S Pouso… - Scientific reports, 2019 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, which is mainly due to
late diagnosis and profound resistance to treatment. The latter is to a large extent attributed …
late diagnosis and profound resistance to treatment. The latter is to a large extent attributed …
Modeling pancreatic cancer with organoids
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy for which new
treatment and diagnostic approaches are urgently needed. For such breakthroughs to be …
treatment and diagnostic approaches are urgently needed. For such breakthroughs to be …