Results Cell plasticity allows adaptative strategies for cancer cells to survive or eventually
escape from tumoral environment through modification of the microenvironment–cell …

Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …

Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …

The tumour microenvironment contributes greatly to the response of tumour cells. It consists
of chemical gradients, for example of oxygen and nutrients. However, a physical …

Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

The malignancy of tumors depends on the biomechanical properties of cancer cells and
their microenvironment, which enable cancer cells to migrate through the connective tissue …

The tumor physical microenvironment (TPME) contributes to cancer chemoresistance in both
mechanical and mechanobiological approaches. Along with chemotherapy, the tumor …

The microenvironment in a solid tumor includes a multitude of cell types, matrix proteins, and
growth factors that profoundly influence cancer cell mechanics by providing both physical …

Background Metastasis refers to the spread of cancer cells from a primary tumor to other
parts of the body via the lymphatic system and bloodstream. With tremendous effort over the …