H Zhou, M Wang, Y Zhang, Q Su, Z Xie… - Cancer …, 2022 - Wiley Online Library
Dynamic and heterogeneous interaction between tumor cells and the surrounding microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …
Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …
A Nagelkerke, J Bussink, AE Rowan… - Seminars in cancer biology, 2015 - Elsevier
The tumour microenvironment contributes greatly to the response of tumour cells. It consists of chemical gradients, for example of oxygen and nutrients. However, a physical …
Q Liu, Q Luo, Y Ju, G Song - Cancer biology & medicine, 2020 - ncbi.nlm.nih.gov
Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …
X Li, J Wang - International journal of biological sciences, 2020 - ncbi.nlm.nih.gov
Metastasis is a complicated, multistep process that is responsible for over 90% of cancer- related death. Metastatic disease or the movement of cancer cells from one site to another …
CT Mierke - Cell biochemistry and biophysics, 2011 - Springer
The malignancy of tumors depends on the biomechanical properties of cancer cells and their microenvironment, which enable cancer cells to migrate through the connective tissue …
Y Li, G Jin, N Liu, H Guo, F Xu - Cancer Letters, 2023 - Elsevier
The tumor physical microenvironment (TPME) contributes to cancer chemoresistance in both mechanical and mechanobiological approaches. Along with chemotherapy, the tumor …
D Ghosh, MR Dawson - Biomechanics in oncology, 2018 - Springer
The microenvironment in a solid tumor includes a multitude of cell types, matrix proteins, and growth factors that profoundly influence cancer cell mechanics by providing both physical …
SJ Han, S Kwon, KS Kim - Cellular Oncology, 2022 - Springer
Background Metastasis refers to the spread of cancer cells from a primary tumor to other parts of the body via the lymphatic system and bloodstream. With tremendous effort over the …