[PDF][PDF] Genome-wide methylation profiles reveal quantitative views of human aging rates

G Hannum, J Guinney, L Zhao, LI Zhang, G Hughes… - Molecular cell, 2013 - cell.com
… we show is impacted by gender and genetic variants. We also show that differences in aging
rates help … Moreover, we show how our aging model is upheld in other human tissues and …

Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs

WT Steegenga, MV Boekschoten, C Lute, GJ Hooiveld… - Age, 2014 - Springer
… Studies examining age-related changes in DNA methylation … allowing genome-wide analysis
of the DNA methylation status … In human samples, age-related changes in DNA methylation

[HTML][HTML] DNA methylation profile is a quantitative measure of biological aging in children

X Wu, W Chen, F Lin, Q Huang, J Zhong, H Gao… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
… data, we observed the following: first, the aging rate appears … exposure early in life increases
the aging rate in boys, but not … We collected publicly available genome-wide methylation

A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects

JL McClay, KA Aberg, SL Clark, S Nerella… - Human molecular …, 2014 - academic.oup.com
… perform genome-wide methylation analyses that are more cost-… We used the quantitative
coverage estimates for the ∼4.3 … may be sufficient for genome-wide methylation analysis (64,65)…

Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring

D Gentilini, D Mari, D Castaldi, D Remondini, G Ogliari… - Age, 2013 - Springer
Genome-wide methylation profile of DNA samples was … This assay determines quantitative
measurements of DNA methylation … The Illumina Custom error model with false discovery rate

Novel regional age-associated DNA methylation changes within human common disease-associated loci

CG Bell, Y Xia, W Yuan, F Gao, K Ward, L Roos… - Genome biology, 2016 - Springer
genome-wide DNA methylomes aged 19–82 years, we identify 71 age-associated differentially
methylated … polymorphisms from the NIH genome-wide association study catalogue. This …

Trends in DNA methylation with age replicate across diverse human populations

S Gopalan, O Carja, M Fagny, E Patin, JW Myrick… - Genetics, 2017 - academic.oup.com
… We investigated genome-wide methylation patterns using saliva- and whole blood-… rate
of significant a-CpGs that we identified by searching the literature for studies that quantitatively

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study

L Kananen, S Marttila, T Nevalainen, J Jylhävä… - BMC genomics, 2016 - Springer
Aging-associated alterations in DNA methylation In this study, the genome-wide DNAmet …
observed in the oldest age group, we hypothesize that rates of methylation level changes at the …

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population

JT Bell, PC Tsai, TP Yang, R Pidsley, J Nisbet… - PLoS …, 2012 - journals.plos.org
… and rate of healthy ageing, we performed genome-wide … with both chronological age and
age-related phenotypes. … ranges of quantitative phenotypes in Twins UK were similar to age-…

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

…, C Gieger, Genetics of DNA Methylation Consortium… - Genome biology, 2021 - Springer
… DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide
… While the rate of chronological aging is constant between individuals, there are inter-…