An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging

T Yuan, Y Jiao, S de Jong, RA Ophoff, S Beck… - PLoS …, 2015 - journals.plos.org
genome-wide DNA methylation patterns change with age [1–6]. Further studies have indicated
that this age… in blood and recomputed statistics of differential methylation for these blocks. …

Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape

K Day, LL Waite, A Thalacker-Mercer, A West… - Genome biology, 2013 - Springer
genome-wide DNA methylation profiling using Illumina beadchips that query 26,486 autosomal
CpGs. Beta scores (percentage methylation; … predictive model of human aging rates from …

[HTML][HTML] DNA methylation correlates of chronological age in diverse human tissue types

N Jain, JL Li, L Tong, F Jasmine, MG Kibriya… - Epigenetics & …, 2024 - ncbi.nlm.nih.gov
age-related expression quantitative trait methylation (age-… the association between age
and genome-wide measures of … first selected age-associated CpG sites, false discovery rate (…

Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

G Sturm, A Cardenas, MA Bind, S Horvath, S Wang… - Epigenetics, 2019 - Taylor & Francis
human DNAm clocks and age indicators track cellular aging in primary cultured fibroblasts,
and compare the rate of aging … DNA methylation was quantified for 866,736 CpG sites using …

Quantitative comparison of genome-wide DNA methylation mapping technologies

C Bock, EM Tomazou, AB Brinkman, F Müller… - Nature …, 2010 - nature.com
… makes RRBS substantially more cost efficient than genome-wide bisulfite sequencing. The
… higher genomic coverage at competitive cost. Methylation-specific digestion was excluded …

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

Y Wang, R Karlsson, E Lampa, Q Zhang, ÅK Hedman… - Epigenetics, 2018 - Taylor & Francis
… Several studies on methylation quantitative trait loci (meQTL) have identified genetic … This
was done by maximizing false positive rate minus sensitivity with a detection p-value cutoff of …

Longitudinal changes and variation in human DNA methylation analysed with the Illumina MethylationEPIC BeadChip assay and their implications on forensic age …

MR Refn, MM Andersen, ML Kampmann… - Scientific Reports, 2023 - nature.com
… In this study, genome-wide methylation profiles of 128 blood … the accuracy of the quantified
DNA methylation level can be … assess the rate of change in DNA methylation with age in this …

Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging

MT Bocker, I Hellwig, A Breiling… - Blood, The Journal …, 2011 - ashpublications.org
… from the same human samples, we obtained detailed methylation profiles at distinct stages
… that are methylated in CD34 + hematopoietic progenitor cells but show pronounced DNA …

Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites

I Florath, K Butterbach, H Müller… - Human molecular …, 2014 - academic.oup.com
… between methylation levels quantified by beta-value and ageGenome-wide DNA methylation
status was measured using … simultaneous quantitative measurement of the methylation

Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome

I Shchukina, J Bagaitkar, O Shpynov, E Loginicheva… - Nature aging, 2021 - nature.com
… We used the MethPipe pipeline 41 to perform a genome-wide comparison of the methylomes
between the two groups, which yielded 1,160 DMRs (Fig. 3f and Supplementary Table 12). …