Testing two evolutionary theories of human aging with DNA methylation data

C Robins, AF McRae, JE Powell, HW Wiener… - Genetics, 2017 - academic.oup.com
… The genome-wide patterns of methylation have been … type I error rate and our power to
detect age-dependent changes … I error and that our power to detect age-dependent changes is …

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

RC Slieker, M van Iterson, R Luijk, M Beekman… - Genome biology, 2016 - Springer
… Initial studies, although small or lacking a genome-wide viewuncover the occurrence of
divergence in DNA methylation with age, we studied 3295 whole-blood DNA methylation profiles

[HTML][HTML] The role of DNA methylation in epigenetics of aging

A Unnikrishnan, WM Freeman, J Jackson… - Pharmacology & …, 2019 - Elsevier
… that predict chronological age based the rate of change in methylation in 3 to … are pairing
genome wide DNA methylation profiles to … with age and is correlated to changes in methylation. …

[HTML][HTML] DNA methylation biomarkers in aging and age-related diseases

Y Salameh, Y Bejaoui, N El Hajj - Frontiers in Genetics, 2020 - frontiersin.org
genome-wide DNA methylation alterations in aging and agerate of epigenetic aging might
help determine such biological processes. Recent genome-wide association studies revealed

Genome-wide DNA methylation changes during aging

KC Johnson, BC Christensen - Epigenomics in Health and Disease, 2016 - Elsevier
rate of methylation change for both age-related and cancer-related CpG sites, whereas aspirin
and hormone replacement therapy reduced the rate … stability of methylation in aging tissue…

Quantitative translation of dog-to-human aging by conserved remodeling of the DNA methylome

T Wang, J Ma, AN Hogan, S Fong, K Licon, B Tsui… - Cell systems, 2020 - cell.com
Genome-wide methylation profiles reveal quantitative views of human aging rates. … For
comparison, we obtained previously published methylation profiles from the blood of 320 human

A meta-analysis of genome-wide association studies of epigenetic age acceleration

J Gibson, TC Russ, TK Clarke, DM Howard… - PLoS …, 2019 - journals.plos.org
… Hannum-EAA GWAS are confounded by methylation quantitative trait loci, we checked for
Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell […

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

CI Weidner, Q Lin, CM Koch, L Eisele, F Beier… - Genome biology, 2014 - Springer
… [19] built a quantitative model of aging using DNAm values of 71 CpG sites that has been …
-converted DNA, an approach that is relatively cost effective and does not require complicated …

Using DNA methylation profiling to evaluate biological age and longevity interventions

DA Petkovich, DI Podolskiy, AV Lobanov, SG Lee… - Cell metabolism, 2017 - cell.com
Genome-wide methylation profiles reveal quantitative views of human aging rates. …
Genome-wide methylation profiles reveal quantitative views of …

[HTML][HTML] DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy

Q Lin, CI Weidner, IG Costa, RE Marioni… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
… site-specifically with quantitative and cost-effective methods, (ii) … Microarray data of genome
wide DNAm profiles of large … a systematic off-set in epigenetic age-predictions, resulting in a …