DNA methylation clocks for dogs and humans

S Horvath, AT Lu, A Haghani… - Proceedings of the …, 2022 - National Acad Sciences
methylation profiles from 742 blood samples derived from 93 dog breeds (Canis lupus familiaris).
Primary characteristics (sex, age… of aging effects (correlation test Z statistics) in humans

Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites

SM Tajuddin, DG Hernandez, BH Chen… - Clinical …, 2019 - Springer
… , we quantified genome-wide DNA methylation levels at single-… in genome-wide age-associated
DNA methylation changes … aging rate of AA men ticks faster before they succumb to age-…

[HTML][HTML] Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

J Higham, L Kerr, Q Zhang, RM Walker, SE Harris… - Genome Biology, 2022 - Springer
… allele-specific methylation or methylation quantitative trait loci (… modelled the rate of change
in DNA methylation with age as … Our genome-wide analyses therefore suggest that local CpG …

Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy

A Witasp, K Luttropp, AR Qureshi, P Barany… - Scientific Reports, 2022 - nature.com
… with high mortality rates and demanding treatment regimens, … we quantitatively identified
genome-wide CpG methylation in … and compared it to the methylation profile in an age- and sex-…

Caloric restriction delays age-related methylation drift

S Maegawa, Y Lu, T Tahara, JT Lee, J Madzo… - Nature …, 2017 - nature.com
methylation status by genome-wide DNA methylation … We find that the rate of epigenetic
drift correlates with lifespan … in methylation drift among species, we utilized a quantitative deep …

Age-related variations in the methylome associated with gene expression in human monocytes and T cells

LM Reynolds, JR Taylor, J Ding, K Lohman… - Nature …, 2014 - nature.com
… discovery rate (FDR) <0.001) gene expression-associated methylationgenome-wide level,
between age and CpG site methylation and transcript expression and CpG site methylation. …

[HTML][HTML] Age-related changes in DNA methylation affect renal histology and post-transplant fibrosis

L Heylen, B Thienpont, P Busschaert, B Sprangers… - Kidney international, 2019 - Elsevier
revealed a significant linear association (false discovery rate [FDR] < 0.05) between donor
age and the extent of methylation … We performed genome-wide DNA methylation profiling on a …

Acceleration of age-associated methylation patterns in HIV-1-infected adults

TM Rickabaugh, RM Baxter, M Sehl, JS Sinsheimer… - PloS one, 2015 - journals.plos.org
… has allowed genome-wide examination of methylation levels… powerful module preservation
statistics that assess whether … package, as this quantitative measure of module preservation …

Linkage of DNA methylation quantitative trait loci to human cancer risk

H Heyn, S Sayols, C Moutinho, E Vidal… - Cell reports, 2014 - cell.com
methylation is a powerful method for improving our interpretation of risk alleles identified in
genome-wide … -scale DNA methylation profiles of 3,649 primary human tumors, representing …

Leveraging DNA-methylation quantitative-trait loci to characterize the relationship between methylomic variation, gene expression, and complex traits

E Hannon, TJ Gorrie-Stone, MC Smart… - … Journal of Human …, 2018 - cell.com
… with human traits, especially because the actual gene(s) involved in mediating phenotypic
variation are not necessarily the most proximal to the lead SNPs identified in genome-wide