… study shows that breast cancer polygenic risk scores already capture sufficient information to
identify a high-risk … Commercial breast cancer risk tests based on polygenic risk scores are …

… These predictors can be found in online tools and combine information associated with
clinical risk factors, such as sex, age, blood pressure, smoking status, family history of …

… Risk Scores are used … Polygenic Risk Scores (PRS). We elucidate the historical advancements
of PRS, their advantages and shortcomings in comparison with other predictive methods, …

… risk factors. You ask yourself whether it is possible to improve clinical decision-making by
adding a polygenic risk score (PRS)… a PRS and clinical risk in the current study also poses new …

… , one may begin to craft PRS as genetic instruments that could be used to test the plausibility
… Improving the Estimation of Polygenic Risk Scores, several techniques can be leveraged to …

… A comprehensive evaluation of polygenic score methods across cohorts in psychiatric …
Conclusions and Relevance Polygenic risk scores will contribute to risk assessment in clinical …

… a score and is referred to as a polygenic score (PGS), polygenic risk score (PRS) or
genetic/genomic risk score (… as part of an integrated risk tool for cardiovascular risk assessment …

… , the frequency of screening, and/or the tools (for example, non-genetic clinical risk scores)
used as part of screening. We provide three examples of screening strategies utilizing PRS. …

… The intersection of public health and clinical medicine Polygenic risk scores have been
proposed both as a tool of clinical medicine and of public health. These two settings come with …

… not be appropriate, to be an objective of future methods development; until then, in such
settings, we recommend that any risk of overlap is minimized through judicious use of target …