… data collection initiatives of diverse populations 5 . Here, we consider the principles and
methods of applying PRSs across global populations, complementing existing reviews on PRS …

… Similar to challenges with transferring predicted BVs across … accuracy and transferability
across populations, especially … Prospective studies offer more real-world insights into the …

… for population genetic structure via PCA, by far the most broadly adopted control method in
… GWAS is adjusted for the discovery cohort’s specific principal components (PCs) (Price et al., …

… that any risk of overlap is minimized through judicious use of … Stringent adjustment of effects
via genetic principal … in a target sample from a different worldwide population from that of the …

… to as polygenic risk scores (PRSs), or genetic or genomic risk … of disease domains, risk
score categories and populations) to … Moving forward, supplementary frameworks should be …

… bring the individual’s risk closer to the population average 7 . … On the basis of equivalent risk
principles, it can be argued … BOADICEA/CanRisk is part of a first wave of PRSs moving into …

… have been leveraged to create polygenic risk scores. We then … in statin benefit was noted
moving from low (bottom 20% of … trial populations attest to a potential role for polygenic risk …

… method for generating multi-ancestry Polygenic Risk scOres … and validation datasets across
diverse populations. The … (23andMe), the Global Lipids Genetics Consortium (GLGC) 37 , …

… in GWAS is transferred to PRS research. Discovery of genetic … While a fraction of risk variants
is likely population-specific, … We used both principal component-based ancestry prediction …

… by the number of risk alleles, starting with the most and moving to the least significant …
constructing polygenic risk scores for ASD, ADHD, and cognitive ability in three general population …