Systematic identification of trans eQTLs as putative drivers of known disease associations
… trans-eQTL analysis focused on 4,542 SNPs that have been implicated in complex disease
… In the discovery data set, we detected trans eQTLs for 1,513 significant trans eQTLs that …
… In the discovery data set, we detected trans eQTLs for 1,513 significant trans eQTLs that …
[HTML][HTML] Causal relationship and shared genetic loci between psoriasis and type 2 diabetes through trans-disease meta-analysis
… mechanisms these conditions have in common. In addition to … relationships and identified
the putative mechanisms involving … disease association studies. Crucially, only one of the loci …
the putative mechanisms involving … disease association studies. Crucially, only one of the loci …
[PDF][PDF] Novel aggregative trans-eqtl association analysis of known genetic variants detect trait-specific target gene-sets
… Further we show an example that the identified trans-associations can be explained using
… Systematic identification of trans eQTLs as putative drivers of known disease associations. …
… Systematic identification of trans eQTLs as putative drivers of known disease associations. …
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
JH Zhao, D Stacey, N Eriksson… - Nature …, 2023 - nature.com
… are known to be therapeutically important and new putative … levels and across local and
systemic sites. Together, these data … Our pQTL study identified twice as many trans associations …
systemic sites. Together, these data … Our pQTL study identified twice as many trans associations …
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases
… in which eQTLs operate and systematically conducted MR … to identify independent
associations in each cis-eQTL locus. … on 228,819 variants with a known interpretation. This set …
associations in each cis-eQTL locus. … on 228,819 variants with a known interpretation. This set …
PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types
… and identified 22 212 eQTLs associated with patient overall survival. Furthermore, we linked
the eQTLs to genome-wide association … (SNPs), the most common type of human genetic …
the eQTLs to genome-wide association … (SNPs), the most common type of human genetic …
Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood
… identify gene sets which have significant evidence of trans-association with groups of known
… To systematically evaluate this, we performed a differential expression enrichment analysis …
… To systematically evaluate this, we performed a differential expression enrichment analysis …
Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci
H Kirsten, H Al-Hasani, L Holdt, A Gross… - Human molecular …, 2015 - academic.oup.com
… -transcript associations, we analyse relations of eQTLs to … small effects which are common
for trans-eQTLs. Exploiting the … detail, we found systematic differences between pseudogene …
for trans-eQTLs. Exploiting the … detail, we found systematic differences between pseudogene …
Dynamic role of trans regulation of gene expression in relation to complex traits
… A 100% proportion of mediation effect indicated that the entire association between an
eQTL and expression of a trans-eGene (direct effect) is explained by effects of the …
eQTL and expression of a trans-eGene (direct effect) is explained by effects of the …
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
… to identify putative key driver genes that contribute to disease 8 . … Here, we systematically
investigate trans-eQTLs as well as … also identified eQTS associations for genes that are known …
investigate trans-eQTLs as well as … also identified eQTS associations for genes that are known …