Artificial intelligence (AI) is not a new idea or field of research. However, recent advancements in computing technology as well as increasing worldwide experience in applying AI to various fields have enabled us to hope that applying it to the medical practice could improve outcomes. The aim of the article was to evaluate potential applications of AI in the clinical practice of gastroenterology. Artificial intelligence algorithms can offer many benefits over the traditional diagnostic, prognostic, therapeutic scores, or non-AI enhanced procedures that we perform today. It can very easily process complex mathematical data, allow using many parameters and highly sophisticated formulas to determine a conclusion, to a degree that would be impractical or impossible for an unaided human to do alone in the clinical practice. This could permit creating significantly more individualized treatments for each patient. As more data becomes available, it can be fed into the algorithm, changing it based on the new data. However, we must be aware that most studies performed today are still early studies, and that their utility still needs to be evaluated in future large-scale studies. Apart from the medical challenges, it must be noted that the large-scale implementation of AI will have challenges related to ethical and financial aspects as well.