A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
AK Manning, MF Hivert, RA Scott, JL Grimsby… - Nature …, 2012 - nature.com
Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the
understanding of the genetic basis of insulin resistance. We hypothesized that genes
implicated in insulin resistance pathways might be uncovered by accounting for differences
in body mass index (BMI) and potential interactions between BMI and genetic variants. We
applied a joint meta-analysis approach to test associations with fasting insulin and glucose …
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the
understanding of the genetic basis of insulin resistance. We hypothesized that genes
implicated in insulin resistance pathways might be uncovered by accounting for differences
in body mass index (BMI) and potential interactions between BMI and genetic variants. We
applied a joint meta-analysis approach to test associations with fasting insulin and glucose …
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
L Palmer, AK Manning, M Hivert, RA Scott… - 2012 - hekyll.services.adelaide.edu.au
Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the
understanding of the genetic basis of insulin resistance. We hypothesized that genes
implicated in insulin resistance pathways might be uncovered by accounting for differences
in body mass index (BMI) and potential interactions between BMI and genetic variants. We
applied a joint meta-analysis approach to test associations with fasting insulin and glucose …
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the
understanding of the genetic basis of insulin resistance. We hypothesized that genes
implicated in insulin resistance pathways might be uncovered by accounting for differences
in body mass index (BMI) and potential interactions between BMI and genetic variants. We
applied a joint meta-analysis approach to test associations with fasting insulin and glucose …
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