A genome-wide association meta-analysis of circulating sex hormonebinding globulin reveals multiple loci implicated in sex steroid hormone regulation

AD Coviello, R Haring, M Wellons, D Vaidya… - PLoS …, 2012 - journals.plos.org
… availability of sex steroid hormones, primarily … hormone-sensitive cancers such as breast
and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of …

[PDF][PDF] A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple

AD Coviello, R Haring, M Wellons - PLoS Genetics - academia.edu
… availability of sex steroid hormones, primarily … hormone-sensitive cancers such as breast
and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of …

Associations of sex hormone-binding globulin and testosterone with genome-wide DNA methylation

R Arathimos, GC Sharp, R Granell, K Tilling, CL Relton - BMC genetics, 2018 - Springer
… leads to differential levels of SHBG in carriers, as a genetic proxy of circulating SHBG levels.
… [13,14,15] and previous genome-wide association studies have identified common variants …

Genome-wide association studies on serum sex steroid levels

L Vandenput, C Ohlsson - Molecular and Cellular Endocrinology, 2014 - Elsevier
… sulfate, testosterone and sex hormone-binding globulin. The variants … This meta-analysis
of GWA data on serum DHEAS levels … Taken together, this study revealed new genetic factors …

Genome-wide association study of sex hormones, gonadotropins and sex hormonebinding protein in Chinese men

Z Chen, S Tao, Y Gao, J Zhang, Y Hu, L Mo… - Journal of Medical …, 2013 - jmg.bmj.com
… Recently, several genome-wide association studies (GWASs) conducted in Caucasians …
genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals

[PDF][PDF] A Genome-Wide Association Meta-Analysis of Circulating Sex HormoneBinding

AD Coviello, R Haring, M Wellons, D Vaidya… - 2012 - academia.edu
Sex hormone-binding globulin (SHBG) is a protein secreted mainly by the liver that … This
analysis revealed evidence for a further three independent signals at the SHBG locus (based on …

Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes

KS Ruth, PJ Campbell, S Chew, EM Lim… - European Journal of …, 2016 - nature.com
hormone-binding globulin (SHBG), which is a glycoprotein … significant in other published
DHEAS meta-analysis data by looking up … did not reveal any additional likely causative variants. …

Sex-specific associations of sex hormone binding globulin with CKD and kidney function: a univariable and multivariable mendelian randomization study in the UK …

JV Zhao, CM Schooling - Journal of the American Society of …, 2021 - journals.lww.com
genome-wide significant SNPs predicting SHBG in men and women from the latest and largest
genome-wide association … another study, a GWAS meta-analysis of 21,791 participants (…

… validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association …

Y Sato, A Tajima, M Katsurayama… - Human …, 2017 - academic.oup.com
… Previous GWASs have revealed that rs2075230 is associated with … by meta-analysis of
the two Japanese male cohorts. … in circulation is bound to sex hormone-binding globulin (SHBG) …

Sex hormone binding globulin and risk of breast cancer: a Mendelian randomization study

NL Dimou, N Papadimitriou, D Gill… - International journal …, 2019 - academic.oup.com
meta-analysis of 10 genome-wide association studies (GWAS) in 21 791 individuals identified
several genomic regions associated with circulating … Figure 2 shows the multivariable IVW …