Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length

T Laisk, V Kukuškina, D Palmer, S Laber… - Human molecular …, 2018 - academic.oup.com
revealed in larger studies. Here, we present the results of a genome-wide association study
(GWAS) meta-analysis … This large-scale GWAS meta-analysis reveals several novel insights …

… of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genomewide association metaanalysis followed by Mendelian …

J Zheng, E Wheeler, M Pietzner… - Arthritis & …, 2023 - Wiley Online Library
… sclerostin using genetic variants across the whole genome revealed a relationship between
… with a range of traits including sex hormonebinding globulin levels, total testosterone, …

Effect of sex hormone-binding globulin on polycystic ovary syndrome: mechanisms, manifestations, genetics, and treatment

C Xing, J Zhang, H Zhao, B He - International Journal of Women's …, 2022 - Taylor & Francis
… by the liver and binds with circulating sex steroids with a high … Citation8 A meta-analysis
revealed that obesity-related metabolic … A recent genome-wide association study (GWAS) and …

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

CE Elks, JRB Perry, P Sulem, DI Chasman… - Nature …, 2010 - nature.com
… To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Research progress on the relationship between sex hormonebinding globulin and male reproductive system diseases

Q Wan, Y Xie, Y Zhou, X Shen - Andrologia, 2021 - Wiley Online Library
… Several studies have revealed that SHBG levels and polymorphisms are also important … A
genome-wide association meta-analysis has found that the SHBG binding sites are involved in …

The association between sex hormone-binding globulin gene polymorphism with bone mineral density

XY Zha, Y Hu, XN Pang, JH Zhu, GL Chang, L Li - Steroids, 2016 - Elsevier
… In a genome-wide association study (GWAS) meta-analysis examined numerous candidate
genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals

Associations between sex hormones, receptors, binding proteins and inflammatory bowel disease: a Mendelian randomization study

F Zou, Y Hu, M Xu, S Wang, Z Wu… - Frontiers in Endocrinology, 2024 - frontiersin.org
… , two sex hormone receptors, sex hormone-binding globulin (SHBG… study revealed the mutual
causal associations between sexGenome-wide association study meta-analysis identifies …

Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function

R Rawal, A Teumer, H Völzke… - Human molecular …, 2012 - academic.oup.com
… barbed-end F-actin binding protein. These two loci account for … replicated the association of
1p36 with circulating TSH levels… , after being activated by hormone binding, translocates as a …

Sex hormone binding globulin: origin, function and clinical significance

C Selby - Annals of clinical biochemistry, 1990 - journals.sagepub.com
Sex hormone binding globulin (SHBG) is a glycoprotein possessing high affinity binding for
17 β-hydroxysteriod hormones such as testosterone and oestradiol. It is probably …

Candidate gene and genome-wide association studies for circulating leptin levels reveal population and sex-specific associations in high cardiovascular risk …

C Ortega-Azorín, O Coltell, EM Asensio, JV Sorlí… - Nutrients, 2019 - mdpi.com
… , in the joint meta-analysis for men and women, they identified five SNPs reaching genome-wide
… This gene encodes a calcium-dependent, phospholipid-binding protein involved in …