Association of genetically predicted serum estradiol with risk of thromboembolism in men: a Mendelian randomization study

M Nethander, J Quester, L Vandenput… - The Journal of Clinical …, 2021 - academic.oup.com
… repercussions of thromboembolism revealed that endogenous … the largest available
genome-wide association study (GWAS) (… obtained from a GWAS meta-analysis of serum estradiol …

Genome-wide association study for circulating fibroblast growth factor 21 and 23

GT Chuang, PH Liu, TW Chyan, CH Huang… - Scientific Reports, 2020 - nature.com
… We also performed meta-analysis pooling our results … revealed lower mRNA levels of
PPARα and PPARγ 20 . These data support that RGS6 may also act as a regulator of circulating

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

E Porcu, M Medici, G Pistis, CB Volpato… - PLoS …, 2013 - journals.plos.org
… a large meta-analysis of genome-wide association studies for serum … Sex differences in
the regulation of thyroid function have generally been linked to the influence of sex hormones

Meta-analysis of genome-wide association studies in> 80 000 subjects identifies multiple loci for C-reactive protein levels

A Dehghan, J Dupuis, M Barbalic, JC Bis… - Circulation, 2011 - Am Heart Assoc
… a genome-wide association analysis of CRP in 66 185 participants from 15 population-based
studies. We sought replication for the genome-wide … We found 18 genome-wide significant …

Genome-wide association study reveals loci with sex-specific effects on plasma bile acids

A Landini, D Ghasemi-Semeskandeh, Å Johansson… - medRxiv, 2022 - medrxiv.org
… haemoglobin, sex hormone binding globulin and estrone … and sex-stratified genome-wide
association meta-analysis of … , oestradiol, sex hormone-binding globulin or other sex-…

Serum sex hormone-binding globulin is a mediator of the association between intrahepatic lipid content and type 2 diabetes: the Maastricht Study

PIHG Simons, O Valkenburg, MPH van de Waarenburg… - Diabetologia, 2023 - Springer
Aims/hypothesis Serum sex hormone-binding globulin (SHBG) has been proposed to act as
a hepatokine that contributes to the extrahepatic complications observed in non-alcoholic …

Genetic effects on serum testosterone and sex hormone-binding globulin in men: a Korean twin and family study

J Sung, YM Song - Asian Journal of Andrology, 2016 - journals.lww.com
… Supporting the role of genetic factors in determining individual differences in TT and SHBG
levels in men, genome-wide association studies (GWAS) and meta-analysis revealed several …

Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone

IM McGrath… - BMC medicine, 2023 - Springer
… the most recent genome-wide association study revealed 42 loci … , albumin, calcium, sex
hormone-binding globulin (SHBG) and … The meta-analysis was conducted in METAL using the …

Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche

C Sarnowski, DL Cousminer, N Franceschini… - Human …, 2021 - academic.oup.com
… Description of the 38 546 women included in the meta-analysis of genome-wide association
… A recent and large UKBB GWAS of testosterone levels and related sex hormone traits …

Putative causal inference for the relationship between obesity and sex hormones in males: a bidirectional Mendelian randomization study

B Wan, N Ma, Z Zhou, C Lv - PeerJ, 2023 - peerj.com
… among BMI, sex hormone-binding globulin (SHBG), … All SNPs were identified from the
genome-wide association study (… recent meta-analysis including data from 28 articles revealed