Embryo development depends upon maternally derived materials. Mammalian oocytes
undergo extreme asymmetric cytokinesis events, producing one large egg and two small
polar bodies. During cytokinesis in somatic cells, the midbody and subsequent assembly of
the midbody remnant, a signaling organelle containing RNAs, transcription factors and
translation machinery, is thought to influence cellular function or fate. The role of the
midbody and midbody remnant in gametes, in particular, oocytes, remains unclear. Here, we …

Embryo development depends upon maternally derived materials. Mammalian oocytes
undergo extreme asymmetric cytokinesis events, producing one large egg and two small
polar bodies (PB). During cytokinesis in somatic cells, the midbody (MB) and subsequent
assembly of the midbody remnant (MBR), a signaling organelle containing RNAs,
transcription factors and translation machinery, is thought to influence cellular function or
fate. The role of the MB and MBR in gametes, in particular, oocytes, remains unclear. Here …