Antimalarial drugs inhibiting hemozoin (β-hematin) formation: a mechanistic update
Digestion of hemoglobin in the food vacuole of the malaria parasite produces very high
quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique
process adopted by Plasmodium sp. to detoxify free heme. Hemozoin formation is a
validated target for most of the well-known existing antimalarial drugs and considered to be
a suitable target to develop new antimalarials. Here we discuss the possible mechanisms of
free heme detoxification in the malaria parasite and the mechanistic details of compounds …
quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique
process adopted by Plasmodium sp. to detoxify free heme. Hemozoin formation is a
validated target for most of the well-known existing antimalarial drugs and considered to be
a suitable target to develop new antimalarials. Here we discuss the possible mechanisms of
free heme detoxification in the malaria parasite and the mechanistic details of compounds …
Antimalarial drugs inhibiting hemozoin (β-hematin) formation: a mechanistic update.
SK Sanjay Kumar, MG Mithu Guha, VC Vinay Choubey… - 2007 - cabidigitallibrary.org
Digestion of hemoglobin in the food vacuole of the malaria parasite produces very high
quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique
process adopted by Plasmodium sp. to detoxify free heme. Hemozoin formation is a
validated target for most of the well-known existing antimalarial drugs and considered to be
a suitable target to develop new antimalarials. Here we discuss the possible mechanisms of
free heme detoxification in the malaria parasite and the mechanistic details of compounds …
quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique
process adopted by Plasmodium sp. to detoxify free heme. Hemozoin formation is a
validated target for most of the well-known existing antimalarial drugs and considered to be
a suitable target to develop new antimalarials. Here we discuss the possible mechanisms of
free heme detoxification in the malaria parasite and the mechanistic details of compounds …
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