We argue that the main reason for the prevailing dissent in path dependence research methods is the futile attempt to capture “path dependence as a whole” within either a single-method research design or a single all-encompassing theoretical mechanism. By delineating two conceptual building blocks, path creation/emergence and positive feedback/lock-in, which rest on different epistemological foundations, we advocate for the application of complementary methods. We further refine our argument by proposing a general axiomatic structure for path dependence as a theoretical concept, which allows us to derive more specific methodological suggestions.