Broadband tunability of the second-harmonic wavelength is achieved in periodically poled silica fibers. A wavelength tuning range of almost 45 nm of the fundamental wave is demonstrated through mechanical compression tuning of the quasi-phase-matched periodic structure. The uniform strain applied along the entire periodic structure enables the spectral profile and the conversion efficiency of the generated second harmonic to be preserved for the full tuning range. To our knowledge, the achieved tuning range realized through this technique is far greater than that possible with uniform periodically poled crystals.