Cardioprotective effects of nanoceria in a murine model of cardiac remodeling
Isoproterenol (ISO), a synthetic β 1 adrenergic agonist is a well-known agent to be
associated with severe cardiotoxicity manifested as marked myocardial necrosis and
fibrosis. Oxidative stress plays a crucial role in mediating ISO induced cardiotoxicity. In
present study, we have investigated the possible protective effect of nanoceria (NC) in ISO
induced cardiac injury. We have given long duration exposure (a total of 10 days) of low
dose ISO (20 mg/kg/day) to investigate the protective effects of NC in chronic cardiac injury …
associated with severe cardiotoxicity manifested as marked myocardial necrosis and
fibrosis. Oxidative stress plays a crucial role in mediating ISO induced cardiotoxicity. In
present study, we have investigated the possible protective effect of nanoceria (NC) in ISO
induced cardiac injury. We have given long duration exposure (a total of 10 days) of low
dose ISO (20 mg/kg/day) to investigate the protective effects of NC in chronic cardiac injury …
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