molecules with no 5′ end caps or 3′ poly (A) tails, which are generated by back-splicing.
Originally, circRNAs were considered to be byproducts of aberrant splicing. However, in
recent years, development of high-throughput sequencing has led to gradual recognition of
functional circRNAs, and increasing numbers of studies have elucidated their roles in
cancer, neurologic diseases, and cardiovascular disorders. Nevertheless, studies of the …