Intrinsically disordered proteins, defying the traditional protein structure–function paradigm,
are a challenge to study experimentally. Because a large part of our knowledge rests on
computational predictions, it is crucial that their accuracy is high. The Critical Assessment of
protein Intrinsic Disorder prediction (CAID) experiment was established as a community-
based blind test to determine the state of the art in prediction of intrinsically disordered
regions and the subset of residues involved in binding. A total of 43 methods were evaluated …

Protein intrinsic disorder (ID) is a complex and context‐dependent phenomenon that covers
a continuum between fully disordered states and folded states with long dynamic regions.
The lack of a ground truth that fits all ID flavors and the potential for order‐to‐disorder
transitions depending on specific conditions makes ID prediction challenging. The CAID2
challenge aimed to evaluate the performance of different prediction methods across different
benchmarks, leveraging the annotation provided by the DisProt database, which stores the …