FeS cluster biogenesis is an essential process in virtually all forms of life. Complex protein
machineries that are conserved from bacteria through higher eukaryotes facilitate assembly
of the FeS cofactor in proteins. In the last several years, significant strides have been made
in our understanding of FeS cluster assembly and the functional overlap of this process with
cellular iron homeostasis. This minireview summarizes the present understanding of the
cytosolic iron-sulfur cluster assembly (CIA) system in eukaryotes, with a focus on information …